Advanced instruments used for earth science missions require improved cooling systems to remove heat from high power electronic components and maintain tight temperature control for sensitive instruments. Mesoscopic Devices proposes to develop a pumped two-phase cooling loop that will provide high heat flux, distributed load cooling (> 100 W/cm^2) in a lightweight system. In Phase I, an extremely compact pump optimized for two phase cooling was demonstrated, along with advanced lightweight cold plates. Pump and cold plate advances in Phase II will further reduce the mass and improve reliability. A complete thermal loop will be constructed and tested to demonstrate the improved pumps and cold plates.