The Southwest Foundation (SFBR) was founded in 1941 as a nonprofit scientific institution by Mr. Tom Slick, a Texas philanthropist. Although the trust indenture provided for activities in almost any field of research, its trustees adopted the policy that the institution would devote itself exclusively to basic biomedical research. The Foundation had a small staff in 1947, and received its first grant from the National Institutes of Health in 1952. In 1959, it occupied a new site with buildings supported by private gifts and an NIH research facilities grant. Numerous facilities have been added subsequently with the aid of an NIH research facilities grant in 1966 and many gifts from private donors