Designated an Alumni of the JLabs facility in Houston TX., Ictero Medical is organized around development and use of a catheter-based, cryoablation system designed to treat gallstone disease. Designated the Cholesafe System systems, the developed approach is offered as a minimally invasive treatment to treat gallstone disease: usefully understood as a catheter-based, cryoablation system that provides definitive treatment for gallstone disease. Requiring only minimal local anesthesia, the approach allows the developed system to be used in the interventional radiology suite - effectively defunctionalizing the gallbladder without having to remove it, providing the benefits of surgery but without the risk.