IBET, Inc. exploits the innovations in analytical instrumentation begun at Artann Laboratories and pursues new independently developed innovations in bioanalytical chemistry and instrumentation. IBET's facilities are equipped with all of the tools and equipment necessary for experimental biophysical chemistry and instrument development. The firm's personnel have extensive experience in biophysical chemistry and the design and construction of laboratory instrumentation, as well as the software needed to collect and analyze the forthcoming data. IBET Inc.'s corporate focus has been on research and development of instrumentation for the biochemical, biophysical, and biomedical sciences. IBET Inc. has developed analytical instruments designed to provide new and unique information about the thermodynamic properties of biologically important macromolecules and their interactions with each other and with small molecule effectors. These instruments address a deficiency in high-throughput thermodynamic methods resulting from the explosive growth in knowledge of DNA and protein sequence information. In addition to the Temperature Profile Spectroscopy instrument designed for rapid, temperature-dependent UV/Vis spectroscopy of biomacromolecules, in partnership with Artann Laboratories, IBET, Inc. has developed a Temperature-Scanning Ultrasonic Analyzer (T-SUSAN) for measurement of sound velocity in liquids employing a newly invented flow-through cylindrical standing wave ultrasonic sensor. The small volume (~tens of ml) and unique flow-through design of the ultrasonic measuring cell allow for rapid, high-precision measurements of molecular order-disorder processes of biochemical and/or pharmaceutical importance.