APSE is a biotechnology company seeking to commercialize technology for the manufacture of RNA at drastically lower cost of goods than current commercial processes. RNA is manufactured in high yields and stabilized by the use of proprietary nanomaterials. Though high-use rate applications for RNA -- RNAi in aquaculture or animal husbandry - are possible, initial focus by APse is agriculture crop protection and improvement. RNA Interference (RNAi) is a natural mechanism of gene expression, and various forms are common in all life. Scientists in all areas of life sciences are working on product development strategies based on harnessing this natural regulatory mechanism which blocks, or down regulates, the expression of specific genes. RNAi is a highly targeted and effective way to impart desired genetic traits without genetic modification and as such can deliver many of the benefits of biotechnology without having to create genetically modified organisms (GMOs). However, the cost to supply the large quantities of RNA needed to service the needs for RNAi applications in broad acre agriculture has been a serious hurdle to future commercial use. Successful execution of Apse manufacturing technology could overcome this limitation. Using well proven large scale fermentation processes, Apse technology allows RNA to be manufactured. Previously, these large scale fermentation processes were not viable because of the high cost incurred in isolating the desired RNA produced in the fermentation process. Apse technology sequesters, inside a protein capsid, the RNA as it is produced thus protecting it from RNAse degradation. This protein capsid protects the RNA allowing subsequent isolation and purification. There is also a high level of interest in using the protein encapsidated RNA as a delivery mechanism. Collaboration projects are underway with two major agriculture companies with discussion continhing with others.
