Conceptual Health Solutions (CHS) technology specializes in the conversion of free-text to structured data for medical data mining and automated processing. CHS will adapt its existing technology to develop a core data infrastructure for the automation of the evaluation of longitudinal clinical data from dynamic DoD health information systems to detect adverse events after use of drugs, vaccine, or other medication. The technology involves medical concept-based indexing, "natural language processing" and controlled medical vocabularies including SNOMED-CT, MedDRA and ICD to normalize data in medical records for data mining of ADE indicators. Automated analysis tools will process potential ADEs and compare results with other ADE monitoring sources such as the FDA. CHS will combine its medical practice specific data management technology with Mayo Clinic''''''''''''''''s medical research and ADE subject matter expertise. The resulting data infrastructure will allow DoD to determine which adverse events put patients at significant risk or increased healthcare expenditure and enable DoD to take evidence-based, targeted risk mitigation steps.