SBIR-STTR Award

Miniature Mass Spectrometer for Liquids Analysis
Award last edited on: 5/13/2005

Sponsored Program
SBIR
Awarding Agency
NSF
Total Award Amount
$557,805
Award Phase
2
Solicitation Topic Code
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Principal Investigator
John Grossenbacher

Company Information

Griffin Analytical Technologies Inc (AKA: Griffin Analytical Technologies LLC)

3000 Kent Avenue
West Lafayette, IN 47909
   (765) 775-1701
   info@griffinanalytical.com
   www.griffinanalytical.com
Location: Single
Congr. District: 04
County: Tippecanoe

Phase I

Contract Number: ----------
Start Date: ----    Completed: ----
Phase I year
2003
Phase I Amount
$99,330
This Small Business Innovation Research Phase I project will explore liquid-phase analysis systems utilizing novel sample introduction methods coupled with an innovative portable mass spectrometer. Much valuable time and chemical information can be conserved through in-situ analysis at the actual point of sample collection. In light of developing needs in industry as well as current environmental and terrorism threats, the need for rapid, definitive, on-site liquid-phase analysis has become an important analytical challenge. Breakthroughs in instrument design and capabilities are key to providing analytical information in a more timely and efficient manner. Current state of the art techniques for analyzing liquids are slow, expensive, laboratory-based, and require extensive operator expertise to collect and interpret the data. The goal of this project is to demonstrate the feasibility of the company's proprietary technology to develop a portable, easy to use, miniature mass spectrometer that will provide a real-time, automated, sensitive, affordable, and reliable method for detecting a wide range of species in liquid-phase samples. The instrument will be deployed in chemical process applications, teaching and academic research laboratories, contaminated environmental sites, and military installations and battlefields, and has the potential to impact society broadly by providing improved monitoring of developing environmental and homeland security threats

Phase II

Contract Number: ----------
Start Date: ----    Completed: ----
Phase II year
2004
Phase II Amount
$458,475
This Small Business Innovation Research (SBIR) Phase II project aims to develop novel instrumentation based on electrospray ionization (ESI) coupled with mass spectrometry for identifying and quantifying chemical species in liquid-phase samples in the field. The goal of this project is to employ an existing Minotaur miniature mass spectrometer (MS) to develop a portable, easy-to-operate detector that will provide real-time and highly sensitive detection of a broad range of chemical compounds in liquid samples in the field. The objectives of the research are to construct, integrate, and optimize an innovative miniature ESI source into the instrument to receive liquid samples and introduce the target analytes to the detector, while minimizing interference from background matrix constituents, and to fully develop and qualify the analytical characteristics and ease-of-use of the instrument during field operations. Commercially this development of the first field portable, miniaturized ESI-mass spectrometer will have commercial applications in several governmental and commercial sectors, and has the potential to impact society broadly by providing improved monitoring of water resources and protection of the public from chemical exposure resulting from hazardous material accidents or acts of terrorism. If successful, this research will lead directly to developments allowing for determination of compounds of biological origin, e.g. biomarkers, which will provide additional dimensions of information as to the content of analytical samples