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SBIR-STTR Award
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SBIR-STTR Award
5
Clonogenic High - Throughput Assay for Screening Radiation Modulation
Award last edited on: 6/11/2020
Sponsored Program
SBIR
Awarding Agency
NIH : NCI
Total Award Amount
$1,999,990
Award Phase
2
Solicitation Topic Code
366
Principal Investigator
Barbara Frederick
Company Information
Suvica Inc
PO Box 3131
Boulder, CO 80307
(303) 921-6680
info@suvica.com
www.suvica.com
Location:
Single
Congr. District:
02
County:
Boulder
Phase I
Contract Number:
75N91019C00038-0-9999-1
Start Date:
00/00/00
Completed:
00/00/00
Phase I year
2019
Phase I Amount
$1
Direct to Phase II
Phase II
Contract Number:
75N91019C00038
Start Date:
00/00/00
Completed:
00/00/00
Phase II year
2019
Phase II Amount
$1,999,989
Clonogenic assays measure the ability of single cells to proliferate and form a colony. This process approximates closely the regrowth and recurrence of tumors after treatment with radiation or chemotherapy providing an assay to screen for drugs that block this process. Yet clonogenic assays are labor intensive and too cumbersome for high throughput screening HTS of compound libraries. Here we propose to develop an HTS system based on a clonogenic endpoint. This proposal is based on a completed Phase I contract wherein we successfully generated Head and Neck Cancer cells amenable to miniaturization into multi well format with automated colony counting. Proof of concept tests using known radiation modulators demonstrate that this system faithfully represents the traditional clonogenic assays. In the Phase II contract we will screen through compound libraries generate additional cell lines to represent other cancer types and develop a fully integrated automated system that plates cells irradiates exposes them to drug and counts colonies. This system will be transferrable to other laboratories. Potential commercial applications include screening libraries for new compounds with the potential to inhibit regrowth of tumors after treatment and to rapidly identify efficacious pair wise combinations among existing oncology agents
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