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SBIR-STTR Award
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SBIR-STTR Award
7
Optical visualization to efficiently guide coronary intervention of chronic total occlusions.
Award last edited on: 10/9/2017
Sponsored Program
SBIR
Awarding Agency
NIH : NHLBI
Total Award Amount
$286,069
Award Phase
1
Solicitation Topic Code
NHLBI
Principal Investigator
Gerald McMorrow
Company Information
Veravanti Inc
2260 152nd Avenue Ne Suite 200
Redmond, WA 98052
(425) 201-6070
info@veravanti.com
www.veravanti.com
Location:
Single
Congr. District:
01
County:
King
Phase I
Contract Number:
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Start Date:
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Completed:
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Phase I year
2017
Phase I Amount
$286,069
Optical visualization to efficiently guide coronary intervention of chronic total occlusions We propose to investigate the use of the Scanning Fiber Endoscope SFE during coronary intervention for chronic total occlusions of the coronary arteries CTO CTOs represent the most challenging angioplasties and often have much higher failure rates compared with standard angioplasty Improved imaging of the obstructed artery has the potential to improve the success of these procedure and outcomes for the patients The SFE is a novel endoscope design in which a single fiber is vibrated at a high speed in a spiral pattern to generate a high definition image It much smaller in caliber compared with typical endoscopes and has been successfully used in other in vitro applications However it is not deliverable into the coronary arteries via typical angioplasty catheters in its current configuration We propose in Aim to modify the current SFE design to make the device more easily deliverable into the coronary arteries while minimizing changes to the imaging quality This will incorporate a novel actuator device and a shortened fiber optic cantilever which will likely lead to better flexibility and deliverability In addition changes in the design of the catheter will allow for tracking along a coronary artery guide extension In Aim of our proposal will test the deliverability of the redesigned catheters in a step approach An in vitro bench top model using conventional angioplasty guides and hemostatic valves will be used with standardized criteria for successfully traversing a guide catheter and guide extension Catheter designs passing Step will be tested in a perfused intact pig heart model using conventional coronary angioplasty equipment Catheters successfully used to image pig heart coronaries will be tested in a human cadaver heart perfused with expired human blood A technique for clearing the artery of blood and imaging the artery in a standard clinical timeframe of minute will be developed Project Narrative This SFE endoscope technology was developed by the University of Washington and licensed to VerAvanti for rapidly bringing to the clinic as a commercial product This project in collaboration with the University of Washington interventional cardiologists will develop a smaller version of the SFE that is deliverable to the coronary artery allowing image guided treatment of CTO
Phase II
Contract Number:
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Start Date:
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Completed:
----
Phase II year
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Phase II Amount
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