SBIR-STTR Award

High-Resolution Non-Cryogenic Magnetoencephalography: Systems-Level Integration
Award last edited on: 5/19/2023

Sponsored Program
SBIR
Awarding Agency
NIH : NIMH
Total Award Amount
$5,100,127
Award Phase
2
Solicitation Topic Code
242
Principal Investigator
Orang Alem

Company Information

QuSpin Inc

331 South 104th Street Suite 130
Louisville, CO 80027
   (303) 325-7733
   info@quspin.com
   www.quspin.com
Location: Single
Congr. District: 02
County: Boulder

Phase I

Contract Number: 1R44MH110288-01
Start Date: 4/1/2016    Completed: 3/31/2018
Phase I year
2016
Phase I Amount
$772,932
We propose to develop a small, fully-integrated, ultra-sensitive, commercial magnetometer that will merge the multi-use and cost-effective attributes of present EEG electrodes with the sensitivity of SQUID sensors. Our device, referred to as a magnetrode, will combine reliable autonomous operation with straightforward multi-channel integration for a robust MEG system capable of high-resolution localization and millisecond-scale timing. The magnetrode electronics and firmware will provide all the automation services necessary for turn-key operation and easy integration into multi-channel systems.

Public Health Relevance Statement:


Public Health Relevance:
Magnetoencephalography (MEG) is perhaps the most promising of the functional imaging techniques neurodevelopment studies and diagnostics of mental illnesses. The goal of this project is to develop an MEG system based on atomic magnetrodes that are equally suited for adult and infant subjects, and that costs less by almost an order of magnitude compared to SQUID-based systems. We expect that successful execution of this project will encourage many more researchers and clinicians to adopt MEG technology, and may lead to important advances in our understanding of human brain development.

Project Terms:
3D Print; Adopted; Adult; Architecture; Automation; base; Brain; Calibration; Cells; Characteristics; Complex; cost; cost effective; Coupled; cryogenics; density; design; design and construction; Development; Devices; Diagnostic; Electrodes; Electroencephalography; Electronics; Fiber; Fiber Optics; Frequencies (time pattern); Functional Imaging; Generations; Geometry; Goals; Head; Heating; Helmet; Hour; Human; Imaging Techniques; improved; Individual; Infant; Lasers; Lead; Magnetism; Magnetoencephalography; Measurement; Measures; Mental disorders; Methods; millisecond; Miniaturization; neurodevelopment; Noise; operation; Patients; Performance; Phase; Polychlorinated Biphenyls; Positioning Attribute; prototype; public health relevance; Research Personnel; Resolution; Safety; sensor; Services; Signal Transduction; Source; success; System; Technology; Testing; Time; time use; vapor; vector

Phase II

Contract Number: 5R44MH110288-02
Start Date: 4/1/2016    Completed: 3/31/2020
Phase II year
2017
(last award dollars: 2022)
Phase II Amount
$4,327,195

We propose to develop a small, fully-integrated, ultra-sensitive, commercial magnetometer that will merge the multi-use and cost-effective attributes of present EEG electrodes with the sensitivity of SQUID sensors. Our device, referred to as a magnetrode, will combine reliable autonomous operation with straightforward multi-channel integration for a robust MEG system capable of high-resolution localization and millisecond-scale timing. The magnetrode electronics and firmware will provide all the automation services necessary for turn-key operation and easy integration into multi-channel systems.

Public Health Relevance Statement:


Public Health Relevance:
Magnetoencephalography (MEG) is perhaps the most promising of the functional imaging techniques neurodevelopment studies and diagnostics of mental illnesses. The goal of this project is to develop an MEG system based on atomic magnetrodes that are equally suited for adult and infant subjects, and that costs less by almost an order of magnitude compared to SQUID-based systems. We expect that successful execution of this project will encourage many more researchers and clinicians to adopt MEG technology, and may lead to important advances in our understanding of human brain development.

Project Terms:
Adopted; Adult; Architecture; Automation; Brain; Calibration; Cells; Characteristics; commercialization; Complex; cost; cost effective; Coupled; cryogenics; density; design; design and construction; Development; Devices; Diagnostic; Electrodes; Electroencephalography; Electronics; Fiber; Fiber Optics; Frequencies; Functional Imaging; Generations; Geometry; Goals; Head; Heating; Helmet; Hour; Human; Imaging Techniques; improved; Individual; Infant; Lasers; Lead; Magnetism; Magnetoencephalography; Measurement; Measures; Mental disorders; Methods; millisecond; Miniaturization; neurodevelopment; Noise; operation; Patients; Performance; Phase; Polychlorinated Biphenyls; Positioning Attribute; Printing; prototype; public health relevance; Research Personnel; Resolution; S-Adenosylmethionine; Safety; sensor; Services; Signal Transduction; Source; source localization; Squid; success; System; Technology; Testing; Time; vapor; Vaporizer; vector