SBIR-STTR Award

Biocatalyst Platform Technology for Enhancing Cometabolic Biodegradation
Award last edited on: 9/24/2021

Sponsored Program
SBIR
Awarding Agency
NIH : NIEHS
Total Award Amount
$1,571,458
Award Phase
2
Solicitation Topic Code
143
Principal Investigator
Fatemeh R Shirazi

Company Information

Microvi Biotech Inc (AKA: Microvi Biotech LLC)

26229 Eden Landing Road
Hayward, CA 94545
   (510) 344-0668
   info@microvi.com
   www.microvi.com
Location: Single
Congr. District: 15
County: Alameda

Phase I

Contract Number: 1R43ES024670-01
Start Date: 8/11/2014    Completed: 2/10/2015
Phase I year
2014
Phase I Amount
$149,988
Hundreds of different harmful pollutants have contaminated valuable water supplies and resources. Many of these contaminants are recalcitrant (resistant to degradation), and their safe and effective removal from water can be cost prohibitive. For example, chlorinated solvents like trichloroethylene and chloroform are likely human carcinogens with myriad health effects at varying kinds and levels of exposure. The US Environmental Protection Agency (EPA) has established a maximum contaminant level (MCL) for TCE in drinking water of 5 (ug/L). Another recalcitrant compound N-Nitrosodimethylamine (NDMA) is also a probable carcinogen with maximum notification levels of 10 ng/L in many states. Collectively, recalcitrant organic pollutants in water affect hundreds of thousands of sites in the United States and severely confound public and private water treatment efforts. Compared with physical and chemical technologies, biological treatment offers the potential for low-energy, reliable, and eco-friendly degradation of these compounds into innocuous products. Even so, existing methods in applying biological technologies and inducing biodegradation of recalcitrant organics via cometabolism suffer from a number of drawbacks that lead to unreliable performance and high costs. This Phase I feasibility seeks to remedy many of the disadvantages with existing biological treatment technologies through a multidisciplinary approach drawing on materials science, applied microbiology, and environmental engineering. The project will develop, construct, test, and optimize a biocatalyst platform technology that can consolidate the treatment of difficult water quality situations safelyand effectively, thereby protecting public health and promoting environmental sustainability. The major outcome of this work will be a proof-of-concept of a novel high performance biocatalytic process for the cometabolic treatment of major contaminants in water. The value proposition of this method includes intensified, targeted performance while limiting waste and reducing capital and operating expenses. Compared with existing methods, the successful outcome of this project has the potential to be a commercial technology-of-choice for water managers and providers, allowing the cost-effective remediation of water supplies and securing significant value for public and private environmental stewardship for future generations.

Thesaurus Terms:
Affect;Applied Research;Base;Biodegradation;Biological;Biological Assay;Biological Availability;Bioreactors;Capital;Carcinogens;Case Study;Chemicals;Chloroform;Cost;Cost Analysis;Cost Effective;Design;Design And Construction;Development;Dimethylnitrosamine;Disadvantaged;Drinking Water;Economics;Effectiveness;Engineering;Environmental Engineering Technology;Evaluation;Excision;Future Generations;Government;Hand;Health;Human;In Situ;Informatics;Interdisciplinary Approach;International;Lead;Left;Legal Patent;Letters;Marketing;Measures;Meetings;Methane;Methods;Microbe;Microbiology;Microorganism;Microorganism Culture;Modeling;N-Nitrosodimethylamine;New Technology;Notification;Novel;Outcome;Oxygen;Performance;Persons;Phase;Pollutant;Polymers;Process;Prototype;Provider;Public Health Medicine (Field);Public Health Relevance;Recovery;Remediation;Resistance;Resources;Response;Science;Secure;Services;Site;Solvents;Superfund Site;Technology;Technology Development;Testing;Time;Trichloroethylene;United States;United States Environmental Protection Agency;Wasting;Water;Water Pollutants;Water Quality;Water Supply;Water Treatment;Work;

Phase II

Contract Number: 2R44ES024670-02A1
Start Date: 8/11/2014    Completed: 5/31/2019
Phase II year
2017
(last award dollars: 2020)
Phase II Amount
$1,421,470

The contamination of the water resources in the United States with hazardous organic compounds continues to pose serious and widespread risks to public health and safety. Hazardous organic compounds include chlorinated solvents, hydrocarbons, disinfection byproducts, pesticides, polyaromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and other xenobiotic (not naturally occurring) organic chemicals. As these compounds comprise a majority of the 275 “high-priority” hazardous substances ranked by the Agency of Toxic Substances and Disease Registry (ATSDR), the United States Environmental Protection Agency (US EPA) and state regulatory agencies have set ambitious treatment goals for these dangerous and often carcinogenic substances. In addition to increased risks for cancer, very small concentrations of hazardous organic compounds have been proven to cause various illnesses including liver or kidney disease, immune dysfunction, nervous system disorders, and hormonal or reproductive defects. The remediation of hazardous organic compounds is difficult and costly. Superfund site managers, municipalities and water suppliers across the country are demanding less expensive and more effective treatment options for hazardous organic compounds than the existing suite of energy-intense and waste-producing conventional technologies. Specifically, there is a need for new technologies to consolidate the treatment of multiple hazardous organic compounds into simple, environmentally friendly, and easy-to-use systems with as minimal process units as possible. This proposal seeks to address this need through a novel enhanced cometabolism technology. In contrast to conventional physical or chemical technologies such as air stripping and activated carbon, this new technology degrades the hazardous organic compounds into harmless byproducts instead of producing a concentrated secondary waste stream. Moreover, this new technology offers significant reductions in energy and maintenance costs compared with chemical or UV oxidation. Flexibly designed as both an in-situ and ex-situ treatment option, this new technology offers reliable performance across a range of dynamic operating conditions to achieve simultaneous degradation of hundreds of hazardous organic compounds. In this Phase II project, a scaled-up pilot plant is designed, constructed, optimized, and tested to treat hazardous organic compounds at a high-profile contaminated site. This project establishes the long-term performance profile for the new technology while engaging the pilot plant in a series of gold-standard stress tests to obtain key operational boundaries. Ultimately, the project establishes the detailed design criteria and technoeconomic analysis necessary for implementing this new technology to address a variety of urgent needs across the Superfund site, municipal drinking water, decentralized treatment, wastewater reuse and recycle, and agricultural and industrial water treatment sectors. The outcome of this project is the development of a first-of-its-kind technology for degrading complex combinations of hazardous organic compounds in water. The successful result of this project holds significant promise in addressing harmful contaminants that are not effectively treatable using existing technologies, and thereby securing substantial value for public and private environmental stewardship for future generations.

Public Health Relevance Statement:
Project Narrative Human health and public safety is directly linked to the quality of our water. Many hazardous compounds in water are very difficult and costly to remove using conventional treatment methods. This project demonstrates a new, environmentally friendly water treatment technology for degrading combinations of hazardous organic compounds to below safe regulatory levels with lower costs than conventional treatment methods.

Project Terms:
Address; Agriculture; Air; Alkanes; Aromatic Polycyclic Hydrocarbons; base; Biodegradation; Biological; Biological Availability; Bioremediations; cancer risk; Capital; Carbon; carcinogenicity; Characteristics; Chemicals; combinatorial; comparative; Complex; contaminated water; conventional therapy; cost; cost effectiveness; Country; Dangerousness; Data; Decentralization; dechlorination; Defect; density; design; design and construction; Detection; Development; disease registry; Disinfection; Dose; drinking water; effective therapy; Engineering; engineering design; Enhancement Technology; Face; feeding; Fermentation; flexibility; Formaldehyde; Frequencies; Future Generations; Goals; Gold; greenhouse gases; Hazardous Substances; Health; Hormonal; Human; Hydrocarbons; Immune System and Related Disorders; Immune System Diseases; In Situ; Industrialization; Industry Standard; interest; interstitial; Kidney Diseases; Kinetics; Letters; Link; Liver diseases; Los Angeles; Maintenance; materials science; Methane; Methods; microbial; microorganism; model design; Modeling; Municipalities; nervous system disorder; new technology; novel; operation; Organic Chemicals; Outcome; oxidation; Oxygen; Performance; Pesticides; Phase; Pilot Projects; Plants; Poisons; pollutant; Polychlorinated Biphenyls; Polymers; Privatization; Procedures; Process; Production; Protocols documentation; prototype; Provider; Public Health; remediation; reproductive; Resources; response; Risk; Safety; scale up; Scanning Electron Microscopy; Secure; Series; Site; Solvents; Speed; Stream; Stress; Stress Tests; Structure; superfund site; System; Technology; Testing; Time; Trichloroethylene; United States; United States Environmental Protection Agency; wasting; Water; water treatment; Work; Xenobiotics