This SBIR project aims to develop an MRI-compatible 12-lead ECG system. Such a system will provide greatly improved physiological monitoring inside the MRI, which is important for imaging severely ill patients (stroke, spine, patients with ischemic histories), and is also key to future MRI-guided interventions and surgeries. Current MRI-compatible ECG monitoring is limited to 4-closely spaced electrodes, and is intended mainly for outpatient imaging. In addition, gradient-induction (VGrad) and magneto-hydro-dynamic (VMHD) artifacts distort the waveform, not allowing for reliable acute-ischemia detection. The 12-lead system will remove these artifacts and provide clean ECG (ECGreal) traces, similar to those measured outside MRI. Our Specific Aims are: Aim #1: MR compatible 12-lead ECG acquisition and transmission We will develop a 3 Tesla MR-compatible ECG acquisition system using 10 MRI-compatible electrodes positioned at standard torso locations, with coaxial-cable transmission lines carrying ECG signals from the electrodes to the MRI
Public Health Relevance: This study is relevant due to difficulties in recording accurate ECGs during MRI scanning of severely ill and critical care patients, such as trauma or ischemic patients, which leads to their exclusion from imaging. However, MRI is an excellent modality to detect acute stroke1, acute spinal injury2, and post- infarction damage3, so improved ECG would lead to improved care. Moreover, 12-lead ECG is the standard-of-care for detecting acute ischemia4, but ischemia indicators frequently are masked by MRI
Thesaurus Terms: 3-D;3-Dimensional;Accessory Sinuses;Acute;Amplifiers;Apoplexy;Arrhythmia;Articulation;Artifacts;Atrial;Back;Brain;Brain Nervous System;Brain Vascular Accident;Cardiac;Cardiac Arrhythmia;Cardiac Atrium;Caring;Cell Communication And Signaling;Cell Signaling;Cerebral Stroke;Cerebrovascular Apoplexy;Cerebrovascular Stroke;Childhood Stroke;Classification;Clinical;Critical Care;Data;Detection;Diagnosis;Disease;Disorder;Dorsum;Ecg;Ekg;Electrocardiogram;Electrocardiography;Electrodes;Encephalon;Exclusion;Frequencies (Time Pattern);Frequency;Future;Heart Arrhythmias;Heart Atrium;Heating;History;Image;Infarction;Intervention;Intervention Strategies;Intracellular Communication And Signaling;Ischemia;Joints;Loinc Axis 4 System;Lead;Location;Mr Imaging;Mr Tomography;Mri;Mri Scans;Magnetic Resonance Imaging;Magnetic Resonance Imaging Scan;Magnetism;Marketing;Masks;Measures;Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance;Methods;Modality;Monitor;Morphologic Artifacts;Nmr Imaging;Nmr Tomography;Nasal Sinuses;Nasal Cavity/Paranasal;Nasal Cavity/Paranasal Sinuses;Noise;Nuclear Magnetic Resonance Imaging;Operative Procedures;Operative Surgical Procedures;Out-Patients;Outpatients;Paranasal Sinuses;Pathology;Patient Care;Patient Care Delivery;Patients;Pb Element;Penetration;Phase;Physiologic Monitoring;Physiologic Pulse;Physiological Monitoring;Position;Positioning Attribute;Predisposition;Premature Ventricular Beats;Premature Ventricular Contractions;Price;Printing;Procedures;Process;Pulse;Rdst;Radio;Recording Of Previous Events;Resolution;Risk;Sbir;Sbirs (R43/44);Scanning;Signal Transduction;Signal Transduction Systems;Signaling;Sinus;Skin;Small Business Innovation Research;Small Business Innovation Research Grant;Source;Spinal;Spinal Column;Spine;Stroke Volume;Surface;Surgical;Surgical Interventions;Surgical Procedure;Susceptibility;System;Systematics;Testing;Time;Transmission;Trauma;V (Voltage);Ventricular Arrhythmia;Ventricular Ectopic Beats;Ventricular Extrasystole;Ventricular Premature Complexes;Ventricular Premature Complices;Vertebral Column;Zeugmatography;Atrium;Backbone;Base;Biological Signal Transduction;Brain Attack;Cerebral Vascular Accident;Cerebrovascular Accident;Computerized Data Processing;Data Processing;Develop Software;Developing Computer Software;Digital;Disease/Disorder;Foot;Heavy Metal Pb;Heavy Metal Lead;Imaging;Improved;Infarct;Interventional Strategy;Magnetic;Meetings;Novel;Patient Population;Pediatric Stroke;Pricing;Radiofrequency;Radiologist;Signal Processing;Software Development;Stroke;Surgery;Transmission Process;Voltage
