SBIR-STTR Award

Caldera Pharmaceuticals will use award-winning XRpro, a high throughput, label-free technology for producing nano-engineered radionuclide decorporation agents that are highly specific for their target radionuclide over similar elements. This proposal displays preliminary results showing specific decorporation agents for Sr(II) that do not bind Ca(II); Sr(II) is the only form of strontium (Sr) that is of concern for decorporation. Decorporation agents specific for elements such as Sr(II) and Co(II), which do not bind any essential metals, including Cu(II), Ca(II), Ni(II), Zn(II) are necessary. Emergency responders are currently forced to use non-selective chelators and blocking agents for radionuclide exposures. Sr-90 is easily obtainable by terrorists who wish to do harm to US citizens, so Sr-90 decorporation is a very high national priority and treatments for Sr-90 exposures remain a critical need for the Strategic National Stockpile. Caldera's specific aims include using highly specific XRpro binding technologies to produce Sr decorporation agents.

Public Health Relevance:
Caldera Pharmaceuticals will use award-winning XRpro, a high throughput, label-free technology for producing nano-engineered radionuclide decorporation agents that are highly specific for their target radionuclide over similar elements. Emergency responders are currently forced to use non-selective chelators and blocking agents for radionuclide exposures. Sr-90 is easily obtainable by terrorists who wish to do harm to US citizens, so Sr-90 decorporation is a very high national priority and treatments for Sr-90 exposures remain a critical need for the Strategic National Stockpile.

Public Health Relevance:
Caldera Pharmaceuticals will use award-winning XRpro, a high throughput, label-free technology for producing nano-engineered radionuclide decorporation agents that are highly specific for their target radionuclide over similar elements. Emergency responders are currently forced to use non-selective chelators and blocking agents for radionuclide exposures. Sr-90 is easily obtainable by terrorists who wish to do harm to US citizens, so Sr-90 decorporation is a very high national priority and treatments for Sr-90 exposures remain a critical need for the Strategic National Stockpile.

Thesaurus Terms:
There Are No Thesaurus Terms On File For This Project.

Caldera Pharmaceuticals will use award-winning XRpro, a high throughput, label-free technology for producing nano-engineered radionuclide decorporation agents that are highly specific for their target radionuclide over similar elements. This proposal displays preliminary results showing specific decorporation agents for Sr(II) that do not bind Ca(II); Sr(II) is the only form of strontium (Sr) that is of concern for decorporation. Decorporation agents specific for elements such as Sr(II) and Co(II), which do not bind any essential metals, including Cu(II), Ca(II), Ni(II), Zn(II) are necessary. Emergency responders are currently forced to use non-selective chelators and blocking agents for radionuclide exposures. Sr-90 is easily obtainable by terrorists who wish to do harm to US citizens, so Sr-90 decorporation is a very high national priority and treatments for Sr-90 exposures remain a critical need for the Strategic National Stockpile. Caldera's specific aims include using highly specific XRpro binding technologies to produce Sr decorporation agents.

Public Health Relevance:
Caldera Pharmaceuticals will use award-winning XRpro, a high throughput, label-free technology for producing nano-engineered radionuclide decorporation agents that are highly specific for their target radionuclide over similar elements. Emergency responders are currently forced to use non-selective chelators and blocking agents for radionuclide exposures. Sr-90 is easily obtainable by terrorists who wish to do harm to US citizens, so Sr-90 decorporation is a very high national priority and treatments for Sr-90 exposures remain a critical need for the Strategic National Stockpile.

Thesaurus Terms:
2-Cyclopentyl-5-(5-Isoquinolylsulfonyl)-6-Nitro-1h-Benzo(D)Imidazole; 90sr; 90y; Affinity; Albumins; Animal Model; Animal Models And Related Studies; Aspiration, Respiratory; Assay; Award; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blood Circulation; Blood Coagulation Factor Iv; Bloodstream; Bone; Bone And Bones; Bones And Bone Tissue; Breathing; Ca++ Element; Calcium; Cell Membrane Permeability; Characteristics; Chelating Agents; Chelators; Chemical Structure; Circulation; Clinical; Coagulation Factor Iv; Complexons; Data; Daughter; Deposit; Deposition; Development; Devices; Divalent Cations; Dose; Drugs; Elements; Emergencies; Emergency Situation; End Point Assay; Endpoint Assays; Equilibrium; Esteroproteases; Excretory Function; Factor Iv; Fluorescence; Height; High Throughput Assay; Human; Human Figure; Human Body; Human, General; Individual; Industry; Inhalation; Inhaling; Inspiration, Respiratory; Ion Channel; Ionic Channels; Ions; Label; Lead; Libraries; Licensure; Man (Taxonomy); Man, Modern; Measurement; Measures; Medication; Membrane Channels; Metals; Methods; Modification; Molecular Interaction; Nih; National Institutes Of Health; National Institutes Of Health (U.S.); Oral; Pb Element; Peptidases; Peptide Hydrolases; Peptides; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Physiologic; Physiological; Predisposition; Process; Proteases; Protein Binding; Proteinases; Proteolytic Enzymes; Protocol; Protocols Documentation; Radioactive; Radioactive Isotopes; Radioisotopes; Radionuclides; Relative; Relative (Related Person); Route; Safety; Serum Albumin; Sr-90; Strontium; Strontium-90; Susceptibility; Technology; Testing; Therapeutic; Time; United States National Institutes Of Health; Y-90; Yttrium 90; Aluminum Phosphate; Balance; Balance Function; Base; Bone; Chelation; Compound-1; Cost; Design; Designing; Dosage; Drug Efficacy; Drug/Agent; Effective Therapy; Excretion; Genotoxicity; Heavy Metal Pb; Heavy Metal Lead; High Throughput Screening; In Vitro Testing; In Vivo; Inspiration; Meetings; Membrane Permeability; Model Organism; Nano Engineering; Nanoengineering; Preclinical Safety; Preference; Public Health Relevance; Respiratory; Response; Scale Up; Small Molecule Libraries