A Tracked MR Hardware/Software System for Motion Robust Pediatric Magnetic Resonance Imaging This research aims to develop improved motion robust magnetic resonance imaging (MRI) technology. Magnetic resonance imaging is a powerful tool that both aids in the diagnosis of individual subjects, guides their clinical care, and provides insights into the mechanisms of normal and atypical development. The characterization of mental health disorders across the lifespan has been facilitated by brain MRI. However, conventional magnetic resonance imaging requires the subject being imaged remain perfectly still for the duration of the image encoding. Young children and adult patients with autism or tuberous sclerosis often have difficulty to hold still long enough for successful imaging. For clinical imaging such patients are frequently sedated or anesthetized, which runs the risk of adverse events, and does not ensure the subjects remain perfectly still. Research studies are typically unable to use sedation or anesthesia due to the possibility of morbidity or mortality. This hampers our ability to identify the neurobiological underpinnings of mental health disorders. The development of motion robust magnetic resonance imaging will enable dramatic improvements in our capacity to chart the trajectory of mental illness over the lifespan. This will have a significant impact on our ability to determine when, where and how to intervene, and enable improved evaluation of potential interventions. This project is a Phase I SBIR in response to the Program Announcement ''Lab to Marketplace: Tools for Brain and Behavioral Research''. The project proposes to utilize a novel combination of hardware for motion tracking and sophisticated post-acquisition processing with scattered data interpolation to enable the construction of high resolution high signal-to-noise ratio images of the brain from subjects who are unable to hold still. In this Phase I study we seek to demonstrate the capacity to compensate for rigid body motion of the head, building on our previous work in the development of MRI compatible tracking hardware, and scattered data interpolation. Successful imaging in the presence of motion will be evaluated through experiments with healthy volunteers and with patients with autism or tuberous sclerosis.
Public Health Relevance: This research aims to develop improved motion robust magnetic resonance imaging technology. The improved imaging technology will be applied and evaluated for its efficacy at enabling high resolution imaging of children and adults at Children's Hospital Boston. Young children and adult patients with autism or tuberous sclerosis often have difficulty to hold still for magnetic resonance imaging. This hampers our ability to identify the neurobiological underpinnings of mental health disorders. The development of motion robust magnetic resonance imaging will enable dramatic improvements in our capacity to chart the trajectory of mental illness over the lifespan. This will have a significant impact on our ability to determine when, where and how to intervene, and enable improved evaluation of potential interventions.
Public Health Relevance Statement: Relevance to Public Health This research aims to develop improved motion robust magnetic resonance imaging technology. The improved imaging technology will be applied and evaluated for its efficacy at enabling high resolution imaging of children and adults at Children's Hospital Boston. Young children and adult patients with autism or tuberous sclerosis often have difficulty to hold still for magnetic resonance imaging. This hampers our ability to identify the neurobiological underpinnings of mental health disorders. The development of motion robust magnetic resonance imaging will enable dramatic improvements in our capacity to chart the trajectory of mental illness over the lifespan. This will have a significant impact on our ability to determine when, where and how to intervene, and enable improved evaluation of potential interventions.
NIH Spending Category: Bioengineering; Brain Disorders; Clinical Research; Diagnostic Radiology; Mental Health; Neurosciences; Pediatric
Project Terms: 0-11 years old; 0-6 weeks old; 21+ years old; Adult; Adverse Experience; Adverse event; Anesthesia; Anesthesia procedures; Articular Range of Motion; Artifacts; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavioral Research; Boston; Bourneville Disease; Bourneville syndrome; Bourneville-Brissaud disease; Bourneville-Pringle syndrome; Brain; Brain imaging; Cell Communication and Signaling; Cell Signaling; Child; Child Youth; Childhood; Children (0-21); City of Boston; Clinical; Clinical Evaluation; Clinical Testing; Clinical Trials, Phase I; Collaborations; Computer Programs; Computer software; Data; Development; Diagnosis; Early-Stage Clinical Trials; Echo-Planar Imaging; Echoplanar Imaging; Encephalon; Encephalons; Ensure; Epiloia; Epiloias; Evaluation; Evaluation Research; Head; History; Human, Adult; Human, Child; Image; Imaging Procedures; Imaging Techniques; Imaging technology; Individual; Infant, Newborn; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Joint Range of Motion; Kanner's Syndrome; Length of Life; Longevity; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Echo-Planar; Magnetic Resonance Imaging, Echoplanar; Measures; Medical; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Planar; Mental disorders; Mental health disorders; Methods and Techniques; Methods, Other; Morbidity; Morbidity - disease rate; Morphologic artifacts; Mortality; Mortality Vital Statistics; Motion; NIH Program Announcements; NMR Imaging; NMR Tomography; Nervous System, Brain; Neurobiology; Newborn Infant; Newborns; Noise; Nuclear Magnetic Resonance Imaging; Output; Patients; Pattern; Pediatric Hospitals; Performance; Phakomatosis, Bourneville; Phase; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Pringle disease; Process; Program Announcement; Protocol; Protocols documentation; Psychiatric Disease; Psychiatric Disorder; Quantitative Evaluations; Radiology; Radiology Specialty; Radiology, General; Range of Motion, Articular; Recording of previous events; Research; Resolution; Risk; Robin; Robin bird; Running; SBIR; SBIRS (R43/44); Safety; Sampling; Scanning; Sedation procedure; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Small Business Innovation Research; Small Business Innovation Research Grant; Software; System; System, LOINC Axis 4; Technics, Imaging; Techniques; Testing; Time; Tuberous Sclerosis; Unspecified Mental Disorder; Work; Zeugmatography; adenoma sebaceum; adult human (21+); base; biological signal transduction; brain visualization; cerebral sclerosis; children; clinical care; clinical test; computer program/software; cost; data acquisition; design; designing; epiploia; experiment; experimental research; experimental study; healthy volunteer; hereditary multiple system hamartomatosis; imaging; improved; insight; interventional strategy; life span; lifespan; mental illness; minimal risk; neurinomatosis centralis; neurobiological; neuromatosis universalis; neurospongioblastosis diffusa; newborn human (0-6 weeks); novel; pediatric; phacomatosis; phase 1 study; phase 1 trial; phase I trial; prospective; protocol, phase I; psychological disorder; public health relevance; public health research; range of motion; reconstruction; research clinical testing; research study; response; sclerosis tuberosa; sedation; sensor; software systems; spongioblastosis circumscripta; tool; tuberose sclerosis; volunteer; youngster
