A multidisciplinary team of researchers seeks to develop novel and economically feasible implantable hemostatic dressings for severe (e.g. arterial) bleeding. Key features of the device under development are its excellent pliability, biocompatibility, and nano/microengineered structure to maximize performance without requiring excessive amounts of procoagulants. LNKChemsolutions LLC and its academic partners will conduct in vitro (e.g., thromboelastography) and in vivo validation studies using a swine model, and focus initially on bandage formulations that are most likely to experience only modest to reasonable regulatory resistance. Long term goals focus on developing partnerships with national and international partners with animal, yeast and/or plant expression platforms for recombinant clotting factors.
Public Health Relevance: This SBIR proposal is a multidisciplinary effort to develop new implantable dressings for hemorrhage control, with emphasis on treatment of severe arterial bleeding situations. Both the civilian and military markets will greatly benefit from important advances in the field.
Public Health Relevance Statement: Project Narrative This SBIR proposal is a multidisciplinary effort to develop new implantable dressings for hemorrhage control, with emphasis on treatment of severe arterial bleeding situations. Both the civilian and military markets will greatly benefit from important advances in the field.
NIH Spending Category: Bioengineering; Hematology; Nanotechnology
Project Terms: Academic Medical Centers; Animal Model; Animal Models and Related Studies; Animal Testing; Animals; Armed Forces Personnel; Autologous Fibrin Tissue Adhesive; Back; Bandage; Behavior; Biochemistry; Biological; Biomedical Engineering; Bleeding; Blood; Blood Clot; Blood Clotting; Blood Coagulation Factor; Blood Plasma; Blood coagulation; Bovine Species; Categories; Cattle; Chemistry, Biological; Classification; Clotting; Coagulation; Coagulation Factors; Coagulation Process; Collaborations; Development; Development and Research; Devices; Dorsum; Dressing; Drug Formulations; Engineering; Engineerings; FDA approved; Family suidae; Femoral Artery; Fibrin Adhesive; Fibrin Glue; Fibrin Sealant; Fibrin Sealant System; Fibrin Tissue Adhesive; Fibrinogen Adhesive; Flexibility; Formulation; Formulations, Drug; Foundations; Generations; Goals; Hemorrhage; Hemostasis; Hemostatic Agents; Hemostatic function; Hemostatics; Human; Human, General; In Vitro; Injury; International; Investigation; Investigators; Kinetic; Kinetics; Lead; Letters; Man (Taxonomy); Man, Modern; Marketing; Mechanics; Medical center; Military; Military Personnel; Modeling; Nanoscale Science; Nanostructures; Nanotechnology; Nebraska; Operation; Operative Procedures; Operative Surgical Procedures; Pb element; Performance; Phase; Pigs; Plants; Plants, General; Plasma; Pliability; Price; Process; Production; Property; Property, LOINC Axis 2; Proteins; R & D; R&D; Recombinants; Red Cross; Research; Research Personnel; Research Resources; Researchers; Resistance; Resources; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Route; Running; SBIR; SBIRS (R43/44); Sampling; Scientist; Serum, Plasma; Small Business Innovation Research; Small Business Innovation Research Grant; Solutions; Staging; Sterile coverings; Structure; Structure of femoral artery; Suidae; Surgeon; Surgical; Surgical Interventions; Surgical Procedure; Swine; Systematics; Temperature; Testing; Thrombase; Thrombelastography; Thrombin; Thromboelastography; Tissel; Toxic effect; Toxicities; Universities; University Medical Centers; Vicryl; Work; Yeasts; animal data; base; biocompatibility; biocompatible polymer; bioengineering; bioengineering/biomedical engineering; biomaterial compatibility; biomedical implant; blood loss; bovid; bovine; clotting factor; cost; cow; design; designing; experience; femoral artery; fibrinogenase; gene product; heavy metal Pb; heavy metal lead; implant device; implantable device; improved; in vitro Model; in vitro testing; in vivo; indwelling device; model organism; multidisciplinary; nano; nano scale Science; nano structured; nano tech; nano technology; nano-structures; nanostructured; nanotech; novel; poly(lactide); polylactide; porcine; pricing; public health relevance; reconstitute; reconstitution; research and development; resistant; scaffold; scaffolding; stem; success; suid; surgery; tisseel; validation studies
