Broad-spectrum therapeutics for influenza is critically needed to address the problem of influenza pandemics, a major threat to the public health globally. We have proposed studies aiming at identifying molecules that are capable of blocking infections of all strains of influenza viruses by targeting the host factors which are essential for activation of all influenza viruses. In this proposed phase I study, we will generate the drug candidates, charactering and compare their biochemical and functional activities in vitro. Our goal is to have two final candidates identified and ready for further preclinical evaluation in phase II study., ,
Thesaurus Terms:, Orthomyxoviridae, antiviral agent, drug discovery /isolation, drug screening /evaluation, influenza, protease inhibitor, cysteine endopeptidase, disease /disorder prevention /control, disease outbreak, drug quality /standard, pharmacokinetics, serine proteinase, subtilisin, trypsin inhibitor, MDCK cell, SDS polyacrylamide gel electrophoresis, chick embryo, electroporation, enzyme linked immunosorbent assay, hemagglutination test, immunoprecipitation, peptide library, polymerase chain reaction, tissue /cell culture
