Magnetic resonance imaging (MRI) has detected breast lesions that had previously been sub clinical (neither palpable nor detected by x ray mammography). However, MRl's 40% false positive detection rate necessitates biopsy of these sub clinical lesions to confirm diagnosis. No device exists that would allow this procedure to be performed without open biopsy. Therefore, we will design a radio frequency (rf) receiver coil for breast MR imaging with integrated stereotaxic capabilities. This coil would perform dual roles: receiving signal from the breast to form an MR image, and allowing MR imaging guided biopsy and needle localizations. This coil will be a modification of the 3 turn solenoidal breast coil T103, designed by the PI, and currently in clinical use on the 1.5 tesla GE Signa imager of MR Imaging center. Coil T103 is IRB approved; FDA approval IS expected later this year. Fifteen hundred centers in the U.S. alone indicate commercial application potential for this biopsy coil.Commercial ApplicationsThe successful development of a stereotaxic breast biopsy coil will allow physicians to detect and biopsy suspected cancerous lesions with significantly greater sensitivity than current methods allow. Estimated market potential for this device is $60 million based on 1,500 imaging centers in the United States.National Cancer Institute (NCI)