The goal of this research is to develop a safe, stable, isotonic, and inexpensive emulsion that will be useful as a cancer preventative and therapeutic agent. The specific aims of this research are: (1) To develop and characterize a lipophilic antioxidant emulsion, with f3-carotene as the active ingredient, and (2) To evaluate the safety and efficacy of this emulsion as both a chemopreventative agent and a chemotherapy agent in animal tumor models. If Phase I demonstrates the feasibility and benefits of treatment with this emulsion, we will then determine the optimum dosage regimen, and evaluate its ability to improve the longevity of individuals and animals suffering from cancer, in Phase II.Awardee's statement of the potential commercial applications of the research:The B-carotene emulsion may be useful directly for the treatment of cancer. As an adjunct to chemotherapy, this emulsion may be useful as a chemotherapeutic agent, in animals and humans. The lipophilic antioxidant emulsion will be useful to researchers studying B-carotene and other antioxidants because it will reduce animal care costs, shorten research testing cycles and lead to investigation at higher antioxidant levels than are possible with orally administered compounds.National Cancer Institute (NCI)
