The goal of this Phase I project is to prove the feasibility of fabricating a small fiberoptic sensor that includes sensing elements for simultaneous measurement of up to three different physical parameters using a single strand of optical fiber, and that can ultimately be produced at reasonable cost.The sensor would be used to measure(1) blood or tissue temperature;(2) blood pressure; and(3) local heat flow, air flow, or blood flow for various clinical applications.In this project, however, the target application is angioplasty. Because the temperature- and flow-sensing combination has already been demonstrated in earlier studies, this Phase I research will concentrate on the combination of temperature and pressure sensing. In Phase II, the proven blood-flow measurement capability will be integrated into the system, forming a final sensor that is capable of measuring all three parameters simultaneously. A successful Phase I program will produce prototypes made with a single optical fiber carrying both the temperature- and pressure-sensing elements. The resulting probe will have a maximum diameter of 1 mm, with potential for further size reduction to 0.5 mm. The prototypes will be tested to determine performance capabilities relative to angioplasty.Awardee's statement of the potential commercial applications of the research:This sensor is an ideal in vivo device for use with angioplasty. It is especially suitable for use with RF or microwave angioplasty. Other applications would be in the area of cardiac output, RF/microwave hyperthermia, and NMR imaging.National Heart, Lung, and Blood Institute (NLBI)
