In this research we will investigate the applicability of 3- dimensional parameters to the structure-activity modelling of mutagenicity. The mutagenic endpoints will be the Ames test, and either the mouse lymphoma o the Syrian hamster ovary cell assay. The parameters to be investigated will include polarizability, electronic charges, moments of inertia and functions of these, area, volume, and molecular cross-sectional area.National Center for Research Resources (NCRR)