Colonoscopy is recognized as a valuable diagnostic tool for the detection of disorders of the colon. However, this procedure is not routinely performed because of its associated cost and time requirements. The object of this program is to develop an improved method for the insertion of a colonoscope that would reduce the insertion procedure - time, eliminate the need for specialty training on insertion techniques, and reduce the risk of trauma to the patient.A method is proposed to employ the existing everting tube technology, as demonstrated in modern catheter insertion techniques, in the design of a fluid-controlled, tip advancement device. The advantages of a mechanism that would pull the scope inward from its forward tip instead of pushing it from its end include increased control and maneuverability of the tip as well as reduced injury from forces applied at the distal end of the scope.The design and construction of prototypes and the evaluation of these devices for manipulation through an anatomical model are proposed for Phase I of this program. Favorable test results during Phase I will be the basis for continued development and evaluation of the system on animal and human subjects during Phase II.National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)