The long-term objectives of this project are to develop a body of knowledge concerning characteristics of monochromatic X-rays and to apply these phenomena to various areas of medical diagnosis.Bone mineral scanning in a fashion similar to instruments using Gd-153 will be accomplished using a modified X-ray generator and an optimized monochromator in conjunction with a moving table. Various detection systems will be evaluated for effectiveness and cost. Spectrum and image processing will be accomplished with an IBM PC/AT or equivalent. Increased speed, higher precision, and accuracy with similar or reduced radiation dose are expected. A constant statistics type scan will be attempted for comparison with the type now produced.In addition to enabling a superior bone mineral analysis technology, some other significant benefits that may be derived from this innovation are: patient dose reduction; generation of quantitative radiographs; enhanced quantitation capabilities for soft tissue small density differences and the soft/hard tissue interfaces in CT imaging; reduction of contrast media quantities used; improved potential for future successful development of digital radiography; and improved diagnosis through more efficient use of k-edge absorption phenomena.National Institute of Arthritis and Muskuloskeletal and Skin Diseases (NIAMSD)
