The proposed work are (a) to design and develop a new generation large power, high brightness, compact structure and low cost column x-ray source, (b) to use the novel new x-ray source to build a large power x-ray laser for a high energy beam weapon. The proposed x-ray source is based on our patented non-conventional x-ray technology. A prototype column x-ray source will be fabricated and its performance including gain coefficient, spectrum, spatial stability and uniformity will be evaluated. The success of this research will significantly advance x-ray laser technology and promote its applications in many important research areas and industries. These applications include x-ray laser weapon in SDI, x-ray microscope for biomedical research and diagnosis, x-ray lithography for fabrication of sub-micron ultra high density semiconductor device and x-ray radiography and holography in non-destructive evaluation of materials and structures.