Innovative Wound Regeneration Support Approaches to Enable Rapid Treatment of Wounded Warfighters
Award last edited on: 3/31/2017

Sponsored Program
Awarding Agency
Total Award Amount
Award Phase
Solicitation Topic Code
Principal Investigator
George Kenneth Lewis

Company Information

ZetrOZ Inc (AKA: Zetroz LLC~Zetroz Systems LLC)

56 Quarry Road
Trumbull, CT 06611
   (888) 202-9831

Research Institution


Phase I

Contract Number: ----------
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Phase I year
Phase I Amount
Therapeutic ultrasound is a common modality for pain management and rehabilitation therapy which has been clinically utilized for 60 years. Specifically designed ultrasonic devices for accelerated healing and wound site debridement are generally hand-operated bulky systems. As such, they are used on a case-by-case basis with irregular therapeutic treatment regimens dependent on patient access and associated treatment costs. This limits ultrasounds effectiveness and its broad-use in the military/civilian wound healing. Recent innovation and FDA regulatory clearances by ZetrOZ in the development of portable, wearable, long duration, low intensity therapeutic ultrasound systems, allows ultrasound to be delivered and sustained for 4 hours of daily therapeutic treatment. Initial studies have demonstrated that the long duration ultrasound device speeds healing in a small-animal wound model and a pilot study of a chronic wound. Here, we propose to modify the device for optimal use in a wound healing scenario, and conduct initial large-animal studies measuring the ability of the device to facilitate accelerated wound closure and healing. The wounds will be assessed both visually and with histological sections. Following completion of this Phase I study, a Phase II study will expand on these results, and obtain GLP animal data for regulatory filings with FDA.

Phase II

Contract Number: ----------
Start Date: ----    Completed: ----
Phase II year
Phase II Amount
Ultrasound is a therapeutic modality which has been used clinically for 60 years, but has been limited in practice by the complexity of the technology. Recent research has allowed for the development of a portable, wearable, long duration, low intensity therapeutic ultrasound system. The system is powered by battery, and can be applied by a user to deliver up