SBIR-STTR Award

CombiMatrix employs CMOS integrated circuitry to produce analog VLSI arrays of individually addressable electrodes. Existing electrode array chips will be modified to make arrays of nanometer-scale ultramicro electrodes. These chips will be used to develop assays for chemical and biological warfare agents. Assays will use highly selective immunochemical methods. The advantageous electrochemical properties of nanodes will be exploited to improve the limits of detection and speed of these biochip sensor devices. Further, CombiMatrix hardware and manufacturing methods allow for multiplexing numerous assays onto a single biochip. Multiplexed assays will be demonstrated.

Benefits:
This proposal will have direct application to development of portable environmental sensor devices, as well as biochip applications such as genomics, proteomics, and drug discovery.

Keywords:
Biochips Nannotechnology Ultramicro Electrode Arrays Immunochemistry Spores Cells Toxins Biosensors

CombiMatrix employs CMOS integrated circuitry to produce analog VLSI arrays of individually addressable electrodes. Existing electrode array chips will continue to be upgraded to make arrays of nanometer-scale ultramicroelectrodes. These chips will be used to develop multiplexed assays for chemical and biological agents, from small molecules such as saxitoxin to cells as salmonella. Assays to be developed will use highly sensitive immunochemical methods and electrochemical detection. The advantageous electrochemical properties of nanodes will be exploited to improve the limits of detection and speed of these biochip sensor devices. Furthermore, CombiMatrix hardware and manufacturing methods allow for multiplexing numerous assays on a single biochip. Multiplexed assays will be part of the final product.

Benefits:
This proposal will have direct application to development of portable environmental sensor devices, as well as biochip applications such as genomics, proteomics and drug discovery.

Keywords:
Biochips Nanotechnology Ultramicro Electrode Arrays Cells Spores Toxins Virus Immunochemistry Bioch