AgonOx is developing OX40 agonists and other immune system activators for use in cancer therapy. Research in the field of T-cell modulation conducted worldwide with OX40 and other agents has demonstrated that the use of T-cell modulating therapies in combination with specific anti-tumor therapies has the potential for yielding benefits for patients with cancer. AgonOx is focused on the development of immune system modulators in combination with other therapies, and is actively seeking combination therapies for in-licensing or partnering. Combination therapies of interest include cytotoxic agents, other immunologic modifiers, and tumor ablation techniques and devices. About OX40: OX40 is a protein transiently expressed on the surface of effector T-cells, but only after activation of the T-cells by immune-stimulating antigens, including tumor antigens. Binding OX40 with either anti-OX40 antibodies or OX40 ligand compositions has been shown to inhibit apoptosis in such T-cells, causing T-cell proliferation, immune attack on tumors, and sometimes very distinct tumor-specific theraputic responses. AgonOx is a spin-off company from the Providence Cancer Center in Portland, Oregon
