Structured around understanding antibody repertoire and focused on identifying and exploiting the universe of relationships between antibodies and antigens, currently (Winter 2020) Serimmune is applying its platform to the development of SARS-CoV-2 (COVID-19) diagnostics, vaccines and therapeutics. Founded in 2014 Serimmune Inc. is an immune intelligence company providing an holistic view of how the body responds to pathogens and other environmental factors -- and then applying that knowledge to improve health and wellness.The company's Serum Epitope Repertoire Analysis (SERA) technology platform applies bacterial display peptide libraries, next generation sequencing, machine learning and custom bioinformatics to reveal the many diverse antigens stimulating immunity. Serimmune's human immunity map is a growing database that can be interrogated to uncover disease information for the development of multiplex diagnostics, vaccines and therapeutics. The firm has biobanked serum samples and analyzed the immune repertoires of thousands of individuals from which data is being compiled a vast database that provides new insights into human health. Antibody serology remains a cornerstone of molecular diagnostics used in hundreds of infectious, autoimmune, and allergy tests. Yet, many existing tests lack desired diagnostic performance and cannot be readily combined into a single platform. The effort by Serimmune is to reveal the compositions of functional immune repertoires, creating new opportunities for therapeutic and diagnostic development. SerImmune maps the distinct antibodies within a repertoire to antigens associated with infections, allergens, microbiome organisms, autoimmune diseases, and cancers. The firm is applying its Digital Serology platform to rapidly develop improved tests for infectious disease (e.g. Lyme disease, Hepatitis) and autoimmune disease (e.g. Celiac disease, Sjogrens) that can be combined (multiplexed) without increasing costs. Potentially hundreds of quantitative results can be reported from a patricksingle assay sample to identify under-diagnosed but treatable health problems.
