SBIR-STTR Award

The objective of this proposal is to demonstrate the feasibility of a new thromboelastograph (TEG)-like instrument that has the same basic capabilities as the TEG – that is to say, capabilities of monitoring in vitro the kinetics, strength, and stability of clot formation in blood samples that are clot induced – but which is miniaturized, highly portable, rugged, and insensitive to adverse environmental conditions. Because current TEG devices use fundamental technology that is difficult to miniaturize and make robust, our approach will incorporate completely different technology and physical processes to measure comparable blood clotting parameters; it will furthermore provide various more advanced testing features.

Keywords:
Thromboelastography, Thromboelastography, Fibrinolysis, Blood Measurements, Hemostasis, Thrombosis, Medical Instruments, Coagulopathy, Teg

Enterprise Sciences, Inc., and the University of Maryland School of Medicine have completed a Navy Phase I STTR feasibility and assessment study validating a new technology for portable devices that detect and monitor coagulopathy in traumatic injury and critically ill patients. This proposal is for a Phase II continuation of this work which will:Complete the validation of the technology with integrated breadboard blood sample testing from coagulopathic animal models; and produce an integrated One-of-Kind Alpha prototype demonstrating the ability to fabricate a rugged portable coagulopathy instrument

Benefit:
This work is expected to produce a rugged portable device to detect and monitor coagulopathy. This device will bring coagulopathy monitoring to the patient at the Point of Care (POC) and provide better management of treatment for trauma and severely ill patients with coagulopathy disorders. The device will be insensitive to the environment and will be able to follow and assist the war fighter in the field.

Keywords:
Rugged, coagulation, TEG, POC, Portable, coagulopathy, blood clotting