Company Profile

Q-State Biosciences Inc
Profile last edited on: 9/24/2021      CAGE: 6XQB7      UEI: WWSMK3N4BCJ7

Business Identifier: All-optical electrophysiology platform for probing rare and genetic CNS conditions and recording activity
Year Founded
First Award
Latest Award
Program Status
Active (Acquired)
Popularity Index
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Location Information

179 Sidney Street
Cambridge, MA 02139
   (617) 945-5433
Location: Single
Congr. District: 07
County: Middlesex

Public Profile

Spun out of research from Harvard University, Q-State Biosciences Inc. is a drug discovery company based on proprietary stem cell and optogenetic technologies. The company is organized around development of precision diagnostics and treatments for disorders involving the nervous and cardiac systems. With expertise in patient-derived stem cells and disease modeling, functional drug screening in neurons and cardiac cells, cardio- and neuro-toxicity testing, and patient satisfaction in clinical trials. Q-State Biosciences has developed an all-optical electrophysiology platform for controlling and recording activity in electrically active cells: primary and human iPSC-derived cardiomyocytes and neurons. The platform combines proprietary ultrasensitive optogenetic actuators, genetically encoded voltage indicators, stem cell technology and advanced optical imaging. Q-State Biosciences uses custom instrumentation and software to probe cellular physiology with sub-micron spatial resolution and sub-millisecond temporal resolution. Q-State technology probes dynamic cellular physiology with far higher throughput and information content than are achieved with manual patch clamp, multi electrode arrays, or calcium- or voltage-sensitive dyes. In Novermber 2018, it was announced that the firm will ally with Minneapolis-based Pairnomix, LLC (“Pairnomix”) to create precision medicine company focused on rare and devastating central nervous system (CNS) diseases.

Extent of SBIR involvement

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Synopsis: Awardee Business Condition

Employee Range
Revenue Range
VC funded?
Privately Held
Stock Info
IP Holdings

Awards Distribution by Agency

Key People / Management

  Jonathan Fleming -- President and CEO

  Matthew Fox -- CEO

  Christina Marie Ambrosino

  Adam E Cohen -- Co-Founder

  Graham Dempsey -- Chief Scientific Officer

  Kevin Eggan -- Co-Founder

  Amy Elder -- Director of Chemistry and Project Manager

  James Fink

  David Gerber -- Senior VP, Scientific Affairs

  Celine Hechard -- Vp Business Development & Sales

  Denise Johnson -- Head of Human Resources/Operations VP

  Joel Kralj -- Co-Founder

  Chani Maher -- Senior Director, Search & Evaluation

  David Margulies -- Co-founder & Executive Chairman

  Owen McManus -- CTO

  Max Milbury -- Controller Manager Finance

  Julieann Rader -- Director of Financial Planning & Analysis

  Stephen John Ryan

  Christopher Werley

  Luis Williams -- Director of Cell Biology

  Yang-Ming Zhu -- Senior Director, Data Analytics & Software Engineering