Company Profile

MEKanistic Therapeutics LLC
Profile last edited on: 9/15/2022      CAGE: 7FHQ9      UEI: LSULPAHTNHN7

Business Identifier: Novel cancer drugs to overcome resistance to targeted therapies
Year Founded
First Award
Latest Award
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Location Information

U-M Venture Accelerator 1600 Huron Parkway:Huron Parkway
Ann Arbor, MI 48109
Location: Single
Congr. District: 06
County: Washtenaw

Public Profile

With strong ties to University of Michigan, MEKanistic Therapeutics is a startup focused on the development of cancer therapeutics. Principals of the firm have discovered and designed small molecules that can selectively hit two cancer targets simultaneously with reduced risk of drug-drug interactions. Anchored in work pioneering the discovery and development of MEK inhibitors -- now in clinical use for the treatment of melanoma -- the computational chemistry expertise of one one the principals complements the cancer biology expertise of the other. The focus is on design of more effective drugs to circumvent resistance mechanisms commonly encountered with currently available kinase-targeted agents. The firm's lead compound, MTX-211, represents a first-in-class molecule that selectively and potently inhibits both of these critical oncogenic kinases, which are known to drive progression in a number of tumor types, including colorectal cancer. Currently, there are no approved treatments for patients diagnosed with metastatic KRAS mutant colorectal cancer. MTX-211 is innovative because it attacks KRAS oncogenic signaling using two independent mechanisms, serving effectively as a combination approach in a single molecule. Firm is listed as having raised $30M in June 2022 but not clear if monies actually allocated.

Extent of SBIR involvement

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Synopsis: Awardee Business Condition

Employee Range
Revenue Range
Less than .5M
VC funded?
Privately Held
Stock Info
IP Holdings

Awards Distribution by Agency

Most Recent SBIR Projects

Key People / Management

  Judith Sebolt-Leopold -- Co-Founder

  Christopher Emil Whitehead -- Co-Founder