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G1 Therapeutics Inc

G1 Therapeutics Inc

Profile last edited on: 12/27/2019
79 TW Alexander Drive 4401 Research Commons Suite 105
Research Triangle Park, NC 27709
  (919) 213-9835
Business Identifier: Myelosuppression treatments
Public Profile:
Spun out of University of North Carolina, G1 Therapeutics, (NASDAQ:GTHX) fka G-Zero Therapeutics Inc, is taking a small molecule-based approach to protecting bone marrow from damage due to chemotherapy or radiation. Damage to the bone marrow results in severe anemia, neutropenia, and thrombocytopenia. G1 Therapeutics' small molecules rapidly capture the cell cycle of hematopoeitic progenitor and stem cells in the bone marrow. This temporary capture -- termed pharmacological quiescence or Pharmacoquiescence (PQ) -- exploits that fact that when cells are detained in Go/G1 of the cell cycle, cells are more resistant to DNA damaging insults. One of the firm's technology applications is for radiation mitigants to treat individuals inadvertently exposed to lethal doses of radiation (radiation accident, atomic bomb, dirty bomb). Another addresses the problem of chemotherapy induced anemia, neutropenia, and thrombocytopenia. G1 Therapeutics is developing trilaciclib, an intravenous cyclin-dependent kinases (CDK) 4/6 inhibitor that is in Phase Ib/II clinical trials for patients with extensive-stage small cell lung cancer, as well as Phase II clinical trial for patients with first-/second-/third-line metastatic triple-negative breast cancer; lerociclib, an oral CDK4/6 inhibitor that is in Phase Ib/IIa clinical trials for the treatment of breast cancer and in Phase Ib/II clinical trial for non-small cell lung cancer; and G1T48, an oral selective estrogen receptor degrader, which is in Phase I clinical trial.

 Synopsis: Awardee Business Condition
Year Founded First SBIR Year Date of Last Award
Employee Range VC funded? IP Holdings
Revenue Range Private/Public Exchange/Symbol :

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Contact information

Innovation Development Institute, LLC

   45 Beach Bluff Avenue, Suite 300
     Swampscott,  MA 01907-1542

  Tel:  (781) 595-2920