Company Profile

Acpharis Inc
Profile last edited on: 11/27/2019      CAGE: 5DK90      UEI: E4Z3M7L7NHT3

Business Identifier: Computational methods to the biomedical problems
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Location Information

160 North Mill Street
Holliston, MA 01746
   (508) 893-0667
Location: Single
Congr. District: 02
County: Middlesex

Public Profile

Acpharis Inc. provides routine and innovative applications of computational methods to the biomedical problems investigated by its partners. Essentially target the right proteins with the right molecules, the firm's computational solvent mapping - determine which proteins are druggable, their binding sites, and when it is necessary to move beyond “Rule of Five” molecules into the frontiers of macrocycles and foldamers - dentifies druggable binding sites and classifies what type of molecules they will bind.The firm's activities include homology modeling of proteins, high throughput virtual screening of databases, and the assessment of compounds in libraries selected by the company's partners; and innovative activities involve the development and use of non-standard drug design technologies and computer programs. The company explores the druggability of target proteins selected by its partners; identifies and characterizes druggable binding sites; and selects functional groups to be used for the design of targeted compound libraries.

Extent of SBIR involvement

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Synopsis: Awardee Business Condition

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VC funded?
Privately Held
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IP Holdings

Awards Distribution by Agency

Most Recent SBIR Projects

Year Phase Agency Total Amount
2022 1 NIH $173,006
Project Title: Deep learning augmented protein mapping software to screen large compound libraries
2019 1 NIH $149,999
Project Title: Software for Antibody Epitope Prediction
2017 1 NIH $150,000
Project Title: Knowledge-based Extensions of Protein-Protein Docking
2017 1 NIH $204,249
Project Title: Development of Structure Based Potential for Protein Mapping
2016 1 NIH $225,000
Project Title: Design of target-specific libraries for fragment based drug discovery

Key People / Management

  Dmitri Beglov -- President and Co-Founder

  David R Hall -- CEO

  Ryan Brenke

  Dima Kozakov -- CTO

  Sandor Vajda -- CSO