SBIR-STTR Award

Auracle: An AI-Enabled Telecare System to Support the Independence and Safety of Individuals with AD/ADRD and Other Dementias
Award last edited on: 2/16/2024

Sponsored Program
SBIR
Awarding Agency
NIH : NIA
Total Award Amount
$2,851,310
Award Phase
2
Solicitation Topic Code
866
Principal Investigator
Mark A Fauci

Company Information

Gen-9 Inc

800 West El Camino Real
Mountain View, CA 94040
   (650) 847-5745
   info@gen9.com
   www.gen9.com
Location: Single
Congr. District: 18
County: Santa Clara

Phase I

Contract Number: 1R44AG071211-01A1
Start Date: 9/15/2021    Completed: 8/31/2022
Phase I year
2021
Phase I Amount
$445,911
Dementia rates are growing at an alarming rate in all regions of the world and are related to population aging. It is estimated that over 30 million people have dementia, with 4.6 million new cases of dementia every year - one new case every 7 seconds. The number of people affected will double every 20 years to 81.1 million by 2040. Most people with dementia live in developing countries (60% in 2001, rising to 71% by 2040). The prevalence of dementia rapidly increases from about 2-3% among those aged 70-75 years to 20-25% among those aged 85 years or more. Alzheimer's disease (AD) is the most common type of dementia among western countries, corresponding to about 60% of cases while vascular dementia (VaD) is the second, with about 20% of all cases. Around 10% of adults over 65 develop mild cognitive impairment (MCI). MCI, while less severe than other forms of dementia, does impact everyday living and is a precursor of Alzheimer's. Dementia caregiving, perhaps more than any other type, places tremendous burdens on the physical, psychological, social, and financial wellbeing of the 4 million people providing informal care to seniors with dementia. Family caregiving, accompanied by emotional strain, was an independent risk factor for mortality among older adults. The majority of family care for older adults with dementia is carried out by either wives or daughters. Home caregiving may have negative acute effects on both psychosocial and physiological responses, especially in daughters. As functional impairment increases, during the course of AD/ADRD, caregivers require more assistance and access to resources to properly manage symptoms and, thereby, avoid an elder's institutionalization. Greater support can also reduce the detrimental impact of stress on the caregiver. Technology that can support caregivers in monitoring the activity, safety and wellbeing of seniors with dementia in the homecare setting can significantly increase the quality of life for seniors and their family members as well as reduce costs to them and the healthcare delivery system. Unfortunately, current, outdated systems are of limited utility. We propose a technically advanced, but easy to use, low cost telecare system called Auracle. Auracle will utilize a unique combination of AI algorithms that will analyze data collected from a mesh network of innovative IoT modules placed throughout the home of the elder being monitored. This highly autonomous system combines a plug and play, compact form-factor with a voice interface. Auracle will be designed to improve the safety, quality of life and wellbeing of people with AD/ADRD or other dementias of aging and provide badly needed support to caregivers who provide their care.

Public Health Relevance Statement:
NARRATIVE Dementia rates are growing at an alarming rate in all regions of the world and are related to population aging. Alzheimer's disease (AD/ADRD) is the most common type of dementia. Delivering care to the AD/ADRD population places enormous psychological, physiological and financial burdens on caregivers who are disproportionately women. We propose a practical, modular, telecare system called Auracle that uses innovative AI methods and IoT hardware and software technologies to support caregivers in providing improved safety, quality of life and well-being for people with AD/ADRD or other dementias of aging.

Project Terms:
Adult; 21+ years old; Adult Human; adulthood; Affect; Elderly; advanced age; elders; geriatric; late life; later life; older adult; older person; senior citizen; Aging; Algorithms; Alzheimer's Disease; AD dementia; Alzheimer; Alzheimer Type Dementia; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's disease dementia; Alzheimers Dementia; Alzheimers disease; Primary Senile Degenerative Dementia; dementia of the Alzheimer type; primary degenerative dementia; senile dementia of the Alzheimer type; Artificial Intelligence; AI system; Computer Reasoning; Machine Intelligence; Communication; Daughter; health care delivery; Healthcare Delivery; health delivery systems; health services delivery; Vascular Dementia; Arteriosclerotic Dementia; vascular contributions to dementia; Developing Countries; Developing Nations; Less-Developed Countries; Less-Developed Nations; Third-World Countries; Third-World Nations; Under-Developed Countries; Under-Developed Nations; developing country; developing nation; Diagnosis; Electronics; electronic device; Expert Systems; Intelligent systems; Family; Healthcare Systems; Health Care Systems; Housing; Institutionalization; Methods; mortality; Personal Satisfaction; well-being; wellbeing; Play; Polychlorinated Biphenyls; PCBs; Polychlorobiphenyl Compounds; polychlorobiphenyl; Production; Quality of life; QOL; Resources; Research Resources; Risk Factors; Safety; Computer software; Software; Stress; Technology; Testing; Vendor; Voice; Woman; Caregivers; Care Givers; Community Healthcare; Community Health Care; Family member; Caring; sensor; improved; Acute; Phase; Physiological; Physiologic; psychologic; psychological; Evaluation; Individual; Wife; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Disturbance in cognition; cognitive dysfunction; cognitive loss; Impaired cognition; System; Country; meter; Amentia; Dementia; psychosocial; novel technologies; new technology; Devices; social; Emotional; Care giver Burden; care giver stress; caregiver stress; Caregiver Burden; response; Functional impairment; functional disability; telecare; Data; Detection; Monitor; Development; developmental; symptom management; manage symptom; caregiving; care giving; cost; design; designing; Population; Prevalence; aged; innovation; innovate; innovative; aging population; aged population; population aging; Secure; mild cognitive impairment; mild cognitive disorder; mobile application; mobile app; mobile device application; cloud based; web portal; internet portal; on-line portal; online portal; web-based portal; family caregiving; family care giving; care recipients; care receiver; informal care; Caregiver support; Care giver support; dementia caregiving; Alzheimer's disease related dementia; AD related dementia; ADRD; Alzheimer related dementia; Financial Hardship; financial burden; financial distress; financial strain; financial stress; intelligent algorithm; smart algorithm; Home

Phase II

Contract Number: 4R44AG071211-02
Start Date: 9/1/2021    Completed: 8/31/2024
Phase II year
2022
(last award dollars: 2023)
Phase II Amount
$2,405,399

Dementia rates are growing at an alarming rate in all regions of the world and are related to population aging. It is estimated that over 30 million people have dementia, with 4.6 million new cases of dementia every year - one new case every 7 seconds. The number of people affected will double every 20 years to 81.1 million by 2040. Most people with dementia live in developing countries (60% in 2001, rising to 71% by 2040). The prevalence of dementia rapidly increases from about 2-3% among those aged 70-75 years to 20-25% among those aged 85 years or more. Alzheimer's disease (AD) is the most common type of dementia among western countries, corresponding to about 60% of cases while vascular dementia (VaD) is the second, with about 20% of all cases. Around 10% of adults over 65 develop mild cognitive impairment (MCI). MCI, while less severe than other forms of dementia, does impact everyday living and is a precursor of Alzheimer's. Dementia caregiving, perhaps more than any other type, places tremendous burdens on the physical, psychological, social, and financial wellbeing of the 4 million people providing informal care to seniors with dementia. Family caregiving, accompanied by emotional strain, was an independent risk factor for mortality among older adults. The majority of family care for older adults with dementia is carried out by either wives or daughters. Home caregiving may have negative acute effects on both psychosocial and physiological responses, especially in daughters. As functional impairment increases, during the course of AD/ADRD, caregivers require more assistance and access to resources to properly manage symptoms and, thereby, avoid an elder's institutionalization. Greater support can also reduce the detrimental impact of stress on the caregiver. Technology that can support caregivers in monitoring the activity, safety and wellbeing of seniors with dementia in the homecare setting can significantly increase the quality of life for seniors and their family members as well as reduce costs to them and the healthcare delivery system. Unfortunately, current, outdated systems are of limited utility. We propose a technically advanced, but easy to use, low cost telecare system called Auracle. Auracle will utilize a unique combination of AI algorithms that will analyze data collected from a mesh network of innovative IoT modules placed throughout the home of the elder being monitored. This highly autonomous system combines a plug and play, compact form-factor with a voice interface. Auracle will be designed to improve the safety, quality of life and wellbeing of people with AD/ADRD or other dementias of aging and provide badly needed support to caregivers who provide their care.

Public Health Relevance Statement:
NARRATIVE Dementia rates are growing at an alarming rate in all regions of the world and are related to population aging. Alzheimer's disease (AD/ADRD) is the most common type of dementia. Delivering care to the AD/ADRD population places enormous psychological, physiological and financial burdens on caregivers who are disproportionately women. We propose a practical, modular, telecare system called Auracle that uses innovative AI methods and IoT hardware and software technologies to support caregivers in providing improved safety, quality of life and well-being for people with AD/ADRD or other dementias of aging.

Project Terms:
Technology; Testing; Vendor; Voice; Woman; Caregivers; Care Givers; Community Healthcare; Community Health Care; Family member; Caring; sensor; improved; Acute; Phase; Physiological; Physiologic; psychologic; psychological; Evaluation; Individual; Wife; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Disturbance in cognition; cognitive dysfunction; cognitive loss; Impaired cognition; System; Country; meter; Amentia; Dementia; psychosocial; novel technologies; new technology; Devices; social; Emotional; Care giver Burden; Caregiver Burden; response; Functional impairment; functional disability; telecare; Data; Detection; Monitor; Development; developmental; symptom management; manage symptom; caregiving; care giving; cost; design; designing; Population; Prevalence; aged; innovation; innovate; innovative; aging population; aged population; population aging; Secure; mild cognitive impairment; mild cognitive disorder; mobile application; mobile app; mobile device application; cloud based; web portal; internet portal; on-line portal; online portal; web-based portal; family caregiving; family care giving; care recipients; care receiver; informal care; Caregiver support; Care giver support; dementia caregiving; Alzheimer's disease related dementia; AD related dementia; ADRD; Alzheimer related dementia; Financial Hardship; financial burden; financial distress; financial strain; financial stress; Home; artificial intelligence algorithm; AI algorithm; Adult; 21+ years old; Adult Human; adulthood; Affect; Elderly; advanced age; elders; geriatric; late life; later life; older adult; older person; senior citizen; Aging; Algorithms; Alzheimer's Disease; AD dementia; Alzheimer; Alzheimer Type Dementia; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's disease dementia; Alzheimers Dementia; Alzheimers disease; Primary Senile Degenerative Dementia; dementia of the Alzheimer type; primary degenerative dementia; senile dementia of the Alzheimer type; Artificial Intelligence; AI system; Computer Reasoning; Machine Intelligence; Communication; Daughter; health care delivery; Healthcare Delivery; health delivery systems; health services delivery; Vascular Dementia; Arteriosclerotic Dementia; vascular contributions to dementia; Developing Countries; Developing Nations; Less-Developed Countries; Less-Developed Nations; Third-World Countries; Third-World Nations; Under-Developed Countries; Under-Developed Nations; developing country; developing nation; Diagnosis; Electronics; electronic device; Expert Systems; Intelligent systems; Family; Healthcare Systems; Health Care Systems; Housing; Institutionalization; Methods; mortality; Persons; well-being; wellbeing; Personal Satisfaction; Play; PCBs; Polychlorobiphenyl Compounds; polychlorobiphenyl; Polychlorinated Biphenyls; Production; QOL; Quality of life; Research Resources; Resources; Risk Factors; Safety; Software; Computer software; Stress