SBIR-STTR Award

Stabilization of Analytes in Blood Cells and Plasma
Profile last edited on: 1/16/2020

Program
SBIR
Agency
NIH
Total Award Amount
$149,998
Award Phase
1
Principal Investigator
Rolf Muller
Activity Indicator

Company Information

Biomatrica Inc

5627 Oberlin Drive Suite 120
San Diego, CA 92121
   (858) 550-0308
   info@biomatrica.com
   www.biomatrica.com
Multiple Locations:   
Congressional District:   52
County:   San Diego

Phase I

Phase I year
2013
Phase I Amount
$149,998
Whole blood remains the cornerstone specimen type used in molecular analysis. Changes in the DNA, RNA, protein, peptide, metabolic, and blood cell analyte levels during pre-analytic specimen handling between collection and eventual molecular analysis impacts testing accuracy and delegitimizes any conclusions drawn from the results. The specific aim of this research is to develop stabilized blood collection devices which effectively preserve analytes at their collection levels, and allow for cold-chain independent shipping and storage. It accomplishes this through the utilization of biostability compounds which stabilize and protect the analytes. What is unique and noteworthy about our proposal is that these particular biostability compounds not only protect soluble analytes such as plasma proteins, but appear to act on the entire cellular fraction, including whole cells and the analytes associated or contained within them. In essence, the biostability compounds arrest the entire blood specimen in its post-collection state, and in a form which is compatible with all downstream molecular analysis. The proposed research will result in the, selection of performance-validated biostability compounds which can be incorporated into standard blood collection tubes or self-draw blood collection devices.

Phase II

Phase II year
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Phase II Amount
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