Awards Registry

Discovering Sources For Atrial Fibrillation: Direct Approach To A Simple Cure
Profile last edited on:

Program
SBIR
Agency
NIH | NHLBI
Total Award Amount
$361,816
Award Phase
1
Principal Investigator
Ruchir Sehra
Activity Indicator

Company Information

Ablation Numerics LLC

5918 Germaine Lane
La Jolla, CA 92037
   (858) 692-1502
   N/A
   N/A
Multiple Locations:   
Congressional District:   52
County:   San Diego

Phase I

Phase I year
2011
Phase I Amount
$361,816
The Institute of Medicine recently listed atrial fibrillation (AF) as its top priority. AF is the most common heart rhythm disorder, afflicting 5 million Americans, in whom it may cause symptoms from irregular heartbeats, stroke, heart failure, and even death. Unfortunately, AF therapy remains limited. Therapy with anti- arrhythmic drugs is poorly tolerated, has frequent side effects and does not reduce complications since AF is not cured. Ablation is a minimally invasive therapy that has attracted considerable recent attention, because it may potentially eliminate AF. Unfortunately, ablation is not widely adopted because it is technically difficult, lengthy (4+ hours), has only <60 % success (compared to >90% for most other arrhythmias), and a 5-10% risk of serious complications. A major cause of these limitations is that AF on the ECG represents many different rhythm disorders (arrhythmia mechanisms), that currently cannot be diagnosed in each patient. As a result, AF ablation cannot be directed to them, and is empiric with extensive destruction of the atrium. Our products represent a disruptive technology that will dramatically improve and simplify AF ablation, rapidly widening its adoption. Our products quickly and accurately diagnose the causal arrhythmias for AF in each individual. Once identified, ablation can be targeted directly at these AF sources for cure. We have substantial preliminary data to support this paradigm. Our AFSourceTM product has for the first time diagnosed localized electrical rotors or repetitive focal beats as the AF mechanism in 42/53 AF patients. Patients in whom these mechanisms were ablated had significantly higher freedom from AF than those in whom ablation did not bisect these sites (92% vs 62% at 2 years, p<0.001). Prospectively, ablation at these sites (known as Focal Impulse and Rotor Modulation therapy, or FIRM) was able to terminate AF in as little as 5.5 minutes (vs. hours for conventional ablation).???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????

Phase II

Phase II year
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Phase II Amount
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