SBIR-STTR Award

Antisense Oligonucleotides Aganist Malaria In Vivo
Award last edited on: 2/25/02

Sponsored Program
SBIR
Awarding Agency
NIH : NIAID
Total Award Amount
$79,635
Award Phase
1
Solicitation Topic Code
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Principal Investigator
Paul C Zamecnik

Company Information

Idera Pharmaceuticals Inc (AKA: Hybridon Inc)

167 Sidney Street
Cambridge, MA 02139
   (617) 679-5500
   info@iderapharma.com
   www.iderapharma.com
Location: Multiple
Congr. District: 07
County: Middlesex

Phase I

Contract Number: 1R43AI043087-01
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
1998
Phase I Amount
$79,635
The objective of this proposal is to initiate in vivo studies examining use of antisense oligonucleotides (AS ODNs) as chemotherapeutic agents to control/prevent malarial infection. This disease afflicts over 200 million people world wide, and is becoming increasingly difficult to treat due to wide spread resistance to currently available anti malarial drugs. New anti malarial compounds are urgently needed. AS ODNs work by specifically inhibiting gene expression of the target protein. We have shown that AS ODNs directed against several different genes in the malarial parasite Plasmodium falciparum can inhibit growth in in vitro culture, and now seek to examine the efficacy of such compounds in vivo. Because P. falciparum infects only humans or some species of monkeys, our initial studies will utilize small animal model systems consisting of the non-human malarial species P. gallinaceum and P. berghei. Studies will examine the effects of dose, frequency and route of administration in controlling infection. Establishing efficacy in these systems will provide the basis for future studies on the human parasite in monkeys, which in turn will lead to human clinical trials. PROPOSED COMMERCIAL APPLICATIONS: The world wide market for anti malarials is estimated between $200-300 million per year, yet increased drug resistance renders many compounds ineffective

Phase II

Contract Number: ----------
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
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Phase II Amount
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