The purpose of this research is to develop a portable pressure pulse delivery system to ameliorate the symptoms of Meniere's disease and possibly related disorders. In Phase I, efforts will be directed to the development of the device itself. In this phase, the primary commitment will be to develop the electrodynamic pressure generator that will deliver the controlled levels and rates of positive or negative pressure pulses to the patient's ear canal. The instrument will be capable of delivering the pressure pulses needed for the initial clinical trials and also be flexible to allow for any subsequent modifications required. In Phase II, the clinical trials and miniaturization of the device will be addressed, as well as preparation for mass marketingAwardee's statement of the potential commercial applications ofthe research: Because 2 4 to 7 5 million Americans have Meniere's disease and because its effects are debilitating, the marketability of a device that can ameliorate the symptoms of the disease should be excellent, particularly for a device that can be used in the homeNational Institute on Deafness and Other Communication Disorders (NICDC)