SBIR-STTR Award

Development of a three dimensional microscopy workstation
Award last edited on: 12/22/14

Sponsored Program
SBIR
Awarding Agency
NIH : NIGMS
Total Award Amount
$50,000
Award Phase
1
Solicitation Topic Code
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Principal Investigator
Robert Frankel

Company Information

Hampshire Instruments

Box 10159 10 Carleson Avenue
Rochester, NY 14610
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Location: Single
Congr. District: 25
County: Monroe

Phase I

Contract Number: 1R43GM035592-01
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
1985
Phase I Amount
$50,000
Understanding three-dimensional structural relationships in cells and tissues is important in both basic medical science and clinical pathology diagnosis. To help address this need, Hampshire Instruments is developing a highresolution three-dimensional optical microscopy workstation with significant computational and interactive graphics capability. This instrument will incorporate three-dimensional deblurring algorithms used to sharpen images from optically sectioned thick specimens, in both absorption and fluorescence microscopy. During Phase I, 1. A microcomputer based high-resolution optical microscopy development system will be constructed; 2. Three-dimensional deblurring algorithms for fluorescence and absorption microscopy will be implemented; 3. The effect of unavoidable partial coherence of illumination in high-resolution microscopy on the validity of threedimensional deblurring algorithms will be determined; 4. Human cancer nuclei cells will be examined to assess the usefulness of three-dimensional deblurring procedures on nuclear features that have been shown to be of prognostic or diagnostic value; and 5. Hardware and software specifications for Phase II construction of the commercial prototype high-resolution three-dimensional optical microscopy workstation will be developed.National Institute of General Medical Sciences (NIGMS)

Phase II

Contract Number: ----------
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
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Phase II Amount
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