With facilities in Durham NC and in Birmingham, AL, BioCryst Pharmaceuticals, Inc. (NASDAQ:BCRX) is a biotechnology company, designing, optimizing, and developing small molecule drugs that block key enzymes involved in the pathogenesis of diseases particuarly those in rare diseases. BioCrystâs ongoing development programs include oral plasma kallikrein inhibitors for hereditary angioedema; avoralstat, BCX7353 and other second generation compounds, and BCX4430, a broad spectrum viral RNA polymerase inhibitor. The firm's product candidates include peramivir, an intravenous neuraminidase inhibitor, which is approved for uncomplicated seasonal and acute influenza; BCX4161, an oral serine protease inhibitor, which is in Phase II clinical trial for hereditary angioedema (HAE); and BCX7353 and other second generation HAE compounds, which are oral serine protease inhibitors that are in preclinical trial for HAE. The companyÂs product candidates also comprise BCX4430, an RNA dependent-RNA polymerase inhibitor that is in Phase I clinical trial for treating Filoviruses, including Ebola and Marburg viruses; and forodesine, an oral purine nucleoside phosphorylase inhibitor that is in Phase II clinical trials for oncology. It has collaborative relationships with Mundipharma International Holdings Limited for the development and commercialization of forodesine; and Shionogi & Co., Ltd. and Green Cross Corporation for the development and commercialization of peramivir in Japan, Taiwan, and South Korea. In 2018, a much discussed merger between BioCryst and Idera Pharmaceuticals wasterminated after BioCryst stockholders voted against the planned combinatio
