Thera Neuropharma is a wholly owned affiliate of Synaerion Therapeutics, a privately held biotechnology company founded by Dr. Antonella Favit-VanPelt (President & CEO) and Mr. Guy Maestre (COO). Thera is developing a new class of disease-modifying small molecules for the treatment of neurologic disorders, initially focusing on Amyotrophic Lateral Sclerosis (ALS) and eventually expanding to traumatic brain injury (TBI), Alzheimer's disease (AD) and multiple sclerosis (MS). Our technology, licensed from Southern Research in Birmingham, AL, is the first and only small molecule regenerative therapy (SMRT) technology that uncovers the therapeutic potential of a dual-target approach that leverages the direct activation of the nuclear factor - ?B p65 (NF-?B p65) subunit and the increase of manganese superoxide dismutase (MnSOD) expression. Thera's small molecules appear to be effective through the simultaneous mitigation of a) oxidative toxicity, b) cell dysfunction, and c) neurotransmission deficit. The multifactorial effect of our compounds translated in the animal model through symptomatic improvement (over 50% reduction in weight loss and over 65% improved neurologic scores), delayed disease progression (higher than 60% permanence at milder disease stages), and increased survival rate: (over 50% increase survival in SOD1 G93A animals treated at disease onset). Thera's broad-spectrum neuroprotective and regenerative compounds exert their potential disease modification effects by protecting neurons against cell toxicity, inducing brain network regeneration, and maintaining functionality by delaying the progression of symptoms of ALS and TBI. Thera has established a number of partnerships to advance our discovery and research program. Thera is also implementing a strong discovery program and we have established important collaborations with Southern Research, Alabama, and the Vlaams Instituut voor Biotechnologie, Belgium, to advance research on our technology platform and small molecule portfolio. Thera offers a unique investment opportunity and we welcome parties interested in investing, strategic partnerships, and collaborations. For more information on Thera Neuropharma, visit our website at www.theraneuro.com
