SBIR-STTR Award

Chronological Sweat Sensor Patch for Real-Time Human Molecular Biomarker Monitoring
Award last edited on: 8/27/2020

Sponsored Program
SBIR
Awarding Agency
DOD : DHA
Total Award Amount
$1,224,993
Award Phase
2
Solicitation Topic Code
DHA18-003
Principal Investigator
Ambalavanan Jayaraman

Company Information

TDA Research Inc (AKA: TDA Research LLC)

12345 West 52nd Avenue
Wheat Ridge, CO 80033
   (303) 422-7819
   research@tda.com
   www.tda.com
Location: Multiple
Congr. District: 07
County: Jefferson

Phase I

Contract Number: W81XWH18C0121
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
2018
Phase I Amount
$150,000
The consequence of physical and mental degraded performance is of critical importance not only to the Department of Defense (DoD) missions and sports persons, but also to the general population as well. Sweat is an information abundant medium that contains biomarkers that show relation to human cognitive levels. However, obtaining days of continuous sampling of sweat from the same dermal spot has proved challenging. Hence, there is a need for a sweat sensor patch that can capture sweat samples in a chronological manner, measure sweat rate, blocks contaminants, conform to the skin, and continuously reports sweat biomarkers.TDA Research proposes to develop and demonstrate a modular microfluidic sweat sensor patch that has the capability to not only carry out real-time monitoring of select biomarkers but also collect multiple precisely time stamped chronological samples for off-line analysis in laboratory assays.

Phase II

Contract Number: W81XWH19C0073
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
2019
Phase II Amount
$1,074,993
Sweat contains biomarkers that give an indication of human cognitive levels. In this SBIR project TDA Research is developing a modular sweat sensor patch that has the capability to not only carry out real-time monitoring of select biomarkers, but also to collect multiple precisely time stamped chronological samples (50-150 Ls each) for off-line analysis in laboratory assays.In Phase I, we demonstrated the collection of multiple precisely time stamped chronological samples of artificial sweat for off-line analysis in a modular sensor patch. Using the same platform, we also demonstrated in breadboard systems the capability to measure sweat rate and biomarkers such as sodium. We also showed that the device itself does not alter the composition of the sweat and does not need any active pumping to move the sweat from the skin into the collection wells.In Phase II, we will further refine the design, fabricate multiple smart sweat patches and demonstrate repeatable and reproducible performance. The device will prevent cross-contamination of the chronologically collected sweat samples, measure sweat rate and include robust biomarker sensors that monitor one or more biomarkers in sweat. We will develop a strategy to secure FDA approval.