Having ceased operations some time in 2018, Sapient Discovery, LLC, had been working in the drug discovery space, offering suite of related services for accelerating the process. The company also offered structural biology services, including protein engineering, cloning and expression, protein purification, protein production services, and X-ray crystallography services along with structural bioinformatics services: target anti-target analysis, annotations, structure based research, protein-ligand interactions, structure analysis, 3D data mining, sequence analysis, and sequence-structure relationships. In the lead optimization arena they had provided protein informatics, virtual library design, structure activity relationship development, and computational prediction of ADMET parameters.