For patietnts diagnosed with sepsis, each hour delay before effective antibiotic treatment is provided, risk of death increases significantly. Hence, new approaches to suppress the systemic consequences of blood-borne bacteria and the endotoxins in the earliest stages of sepsis represent an urgent, unmet need with clear potential clinical impact. Currently resident in JLab Houston, Path Ex is structured around development of a technology that will remove pathogens and endotoxins to treat sepsis. The PATH EX device - designated CycloPE - is being developed to treat septic patients in the intensive care unit (ICU) setting of hospitals. The patient's blood continuously circulated through the CycloPE platform using a method similar to renal replacement therapy (i.e. hemodialysis or hemofiltration). Result: direct bacterial and endotoxin removal from patient -- a novel methodthat eliminates the time consuming, 2-day step of bacterial culture prior to bacterial identification. The firm's approach breaks the paradigm of current sepsis treatment protocols by rapidly eliminating the infectious agents, including multi-drug resistant variants, that lead to sepsis and sepsis progression â rather than applying non-specific and/or ineffective antibiotics. Path Ex's inertial-based fluidic platform can separate and immobilize bacteria from continuously flowing whole blood, avoiding obstacles to translation that limit blood purification therapies that utilize membrane-based column filters for removal of inflammatory mediators and other toxins from blood. The PATH EX technology can be used as a Class I diagnostic, rapidly capturing pathogens from blood samples. The captured pathogens can then be identified and analyzed using MALDI-TOF or PCR.