Originally acquired by Becton Dickinson in 1999, in 2005 - with Clontech Laboratories was no longer a good match to BD - the firm was sold to Takara Bio. and is now a wholly-owned subsidiary of Takara Bio Inc., developing, manufacturing, and distributing a wide range of life science research reagents under the Clontech® and Takara® brands. Key products include SMARTer® cDNA synthesis kits for a variety of samples and applications, including NGS; high-performance qPCR and PCR reagents (including the TaKaRa Ex Taq®, TaKaRa LA Taq®, Titanium®, and Advantage® enzymes); RT enzymes and SMART library construction kits; the innovative In-Fusion® cloning system; Tet-based inducible gene expression systems; Living Colors® fluorescent proteins; and a range of Macherey-Nagel nucleic acid purification