To address the Office of the Secretary of Defense (OSD) need to perform noninvasive neuromonitoring of patients with traumatic brain injury (TBI), Physical Optics Corporation (POC) proposes to develop a new Screening of Cerebral Autoregulation and Neuroelectric signals through Hemodynamic Impedance Measurement and Electroencephalography (SCANHIME) system. It is based on recording brain neuronal activity using electroencephalography (EEG) and hemodynamic impedance variations using rheoencephalography (REG) to monitor and issue alerts on ischemic penumbra and neuropathological conditions. The innovation in hybrid integration of electrodes for both EEG and REG, optimization of electrode disposition, and a new artifact-removal algorithm, enables the SCANHIME to serve as a portable monitor on the battlefield. Therefore, SCANHIME offers inexpensive and reliable ambulatory monitoring of neurophysiological conditions in unattended TBI individuals for >30 days, with an 80 GB memory, which directly addresses the OSD requirements. In Phase I, POC will demonstrate, through modeling, analysis, and performance bound calculations based on a four-shell model of the head, the capability of SCANHIME to perform real-time monitoring with latencies of 2 seconds, and will develop component specifications. In Phase II, POC will develop a SCANHIME prototype, including a display for visualization of measurements, for human and animal studies.
Keywords: Cbf Autoregulation, Icp, Vasospasm, Hypoxia, Ischemia, Edema, Neuromonitoring, Eeg, Reg
