. Tech Seekers are reminded that though these Capability Statements may likely include those of SBIR Awardees who are responsive to their Issued Topics with prepared White Papers, this area of the site is
that customized process and will usually have a more general applicability.
| What should be in my company Nutshell? |
| Number of Active Nutshells to date: 30 |
| Name of Firm |
City, State |
Company Nutshell |
Business Profile |
| Advanced Materials and Processes |
San Marcos, TX |
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Advanced Materials and Processes performs R&D in advanced materials with specialty in polymers and coatings using organometallic and/or biobased r-aw materials; and high efficiency fiber processes for extraction and/or reaction
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| Aspen Aerogels Inc |
Northborough, MA |
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Aspen Aerogel is a striking example of a firm coming to the event out of space that, at first blush, would appear to have remarkably little do with th-e primary areas of primary interest to Novartis OTC. Capitalizing on proprietary and patented advances in aerogel technology, the firm has developed a proprietary, easy-to-use blanket form of aerogels with broad application to a variety of markets including Oil & Gas, Building & Construction, Outdoor Gear & Apparel, Solar Thermal, Appliances and Transportation. Aspen Aerogels, Inc. provides aerogel technology for thermal/acoustic insulation, IR suppression, and shock absorption. AAI manufactures a unique flexible blanket (Cryogel, Spaceloft,and Pyrogel), powder, beads, and clear monolithic sheets. They are bringing nanotechnology to outdoor apparel, footwear, and other gear. Aspen's aerogel insulation, with its nano-sized air pockets that block cold and heat, offers higher thermal performance than any other insulation material - at a fraction of the thickness and weight. The firm has proven its aerogel insulation in boots, jackets, and sleeping pads tested in the most extreme environments on Earth - from the frigid summit of Mt. Everest to the blistering floor of Death Valley. A significant challenge in pharmaceutical development is achieving therapeutically acceptable solubility and bioavailability for poorly soluble drug compounds, while limiting toxicity. Aerogels are ultra low density, high surface area solid materials made by supercritical drying of wet gels. Literature has demonstrated that aerogel scaffolds can be loaded with small molecule drugs, whose dissolution profiles depend on the aerogel microstructures, and can range from immediate to prolonged release. There appear to be no commercial exploitation as yet; additionally, the patent landscape is sparsely populated. Aspen’s extensive experience designing, manipulating, processing, and testing aerogels positions the company to make efficient progress developing materials for this application. Academic relationships in this area are now in place and the firm plans to pursue government funding to corroborate our hypotheses. There would be significant value in a meaningful relationship with a company interested in commercial applications and willing to partner on the government funded R&D work. Aspen is developing aerogels as oral drug delivery systems to improve dissolution of BCS Class II and Class IV small-molecule pharmaceuticals. The firm has begun to test several OTC drug and aerogel composites, focused on immediate dissolution, to provide improved solubility and bioavailability and faster relief. By maximizing solubility, aerogel carriers allow immediate bioavailability which lowers the time taken for the drug to enter the bloodstream, total dosage required and drug toxicity. It is postulated that aerogel carriers increase drug solubility and dissolution due to its ability to stabilize the drug in an amorphous state, through interactions with the aerogel matrix.
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| Axion Biosystems LLC |
Atlanta, GA |
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Specializes in neural interfacing technologies with wide applicability to the research, clinical, and drug discovery markets. Technology allows simult-aneous stimulation and recording of neural tissue - an industry first - and includes low-power chips that service thousands of channels. Current development focused on pharmaceutical drug screening. Ongoing development will result in devices in the medical arena.
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| Biorasis Inc |
Storrs, CT |
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Biorasis owns the rights to a portfolio of patents that collectively provide the means to create a generic sensor platform for use in the drug develop-ment market (pre-clinical research) the animal nutrition market (production and performance of farm animals) and the human diabetes market (diabetes management). The technologies behind Biorasis multi-bioanalyte, miniaturized, continuous, implantable sensor monitoring system, integrate chemistry, biology, pharmacy, biochemical and electrical engineering sciences. The Biorasis sensor platform: (i) addresses many of the deficiencies of the current state of the art drug development methods/ experimentation techniques by decreasing the cost and time for drug development; (ii) improves the production of animal farmers by optimizing the conditions for animal growth providing a totally organic environment for animals to grow while at the same time increasing their performance and production; and (iii) provides a sensor platform that answers the needs and requirements of the diabetes community for tight continuous - long term glucose monitoring improving the lives of millions of diabetics worldwide.
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| Cambridge Polymer Group Inc |
Boston, MA |
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Cambridge Polymer Group, Inc. is a contract research laboratory specializing in polymers. Cambridge Polymer Group provides routine analytical testing -on materials, custom test design, consultation, and out-sourced research assistance. Cambridge Polymer Group assists clients in developing new materials, design of prototypes for proof-of-concept studies, experimental design and data collection for patents and fund-raising, and development of new materials for targeted applications
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| Catacel Corporation |
Garrettsville, OH |
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| Heat exchanging, catalytic reaction solutions for fuel cell manufacturers and hydrogen plant designers to increase system efficiency and durability, a-nd reduce plant cost. Expertise in foil-based catalytic structures, reactor design, and catalytic chemistry, firm’s products and materials are used globally for high throughput reactions in fuel cells, gas-to-liquid, combustion and hydrogen systems, as well as in other chemical reaction or production applications. ...more |
| Ceralink Inc |
Troy, NY |
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Technology commercialization company specializing in materials consulting, R&D, microwave technology and scale up, materials analysis, and lean gr-een engineering
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| CFD Research Corporation |
Huntsville, AL |
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CFD Research Corporation (CFDRC) is long-time and effective SBIR involved firm focused to developing cutting-edge work across many areas of technology-. Building out from sophisticated research and engineering capabilities honed in the military, space, materials and energy arenas, CFD has more recently achieved comparable competencies in the Biomedical, Life Science and Pharmaceutical fields. Over the past 20 years, CFDRC has culminated significant Intellectual Assets (technologies, custom software, expertise, and patents) that can now be directed and applied to provide significant time and cost savings and competitive advantage to its industry partners. CFDRC is an independent small business and has full flexibility for responding to specific needs of its industry partners. Areas of technology focus in CFDRC’s Biomedical Division include development of prototypes and provision of custom solutions for: o Microfluidic systems (lab-on-chip) for bio diagnostics, genomics, proteomics and cell based assays. o Biomedical devices (catheters, inhalers, drug delivery systems) and sensors for healthcare and life science research and other applications. o Bio-inspired power sources (Bio-Battery) for portable power applications.
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| Design By Analysis Inc |
New Britain, CT |
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Design By Analysis, Inc (DBA) is a full service mechanical engineering consulting business. The firm specializes in mechanical product development, pa-rticularly in applications to distributed power systems, turbo-machinery, precision equipment, test equipment , and electronic packaging. Design By Analysis provides advanced technology solutions to the aerospace industry using state-of-the-art tools. DBA has provided customized design and analysis for highly engineered, precision mechanical systems, subsystems and components. DBA's analytical team works in the areas of structural analysis, vibration, thermal/heat transfer and computational fluid dynamics (CFD). Each of DBA's analysts has over twenty years of experience performing finite element analysis. DBA's analysis efforts have solved problems for products already in use, enabled modifications to be made to existing products and provided the technical foundation for totally new concepts.
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| Dynamic Clinical Systems Inc |
Hanover, NH |
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| Patient-centered, interdisciplinary practices of c-are supported by automated, self-reported patient and clinician survey data. Integrated Survey Syst-em™ - ISS - secure Web-based solution featuring customized patient surveys, clinical observation tools, and outcomes reports. ISS easily integrates into any systems environment. Provides: * Automated customizable patient surveys * Validated or "general use" surveys for accurate reporting and tracking * User-friendly patient tools to enhance patient / clinician communication * Adaptable clinician tools for clinical observations * Rapid input and output ...more |
| Glycosyn Inc |
Medford, MA |
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| With declared focus of the firm on reducing/eliminating infant and childhood diarrhea worldwide - primary cause of morbidity and mortality among child-ren - Glycosyn, Inc. is biotechnology therapeutics and diagnostics company developing products for traveler’s diarrhea and animal health, as well as diagnostics and therapeutics targeting necrotizing enterocolitis and other conditions. Formed to commercialize discoveries from three decades of pioneering academic research by three scientific founders associated to Harvard/Massachusetts General Hospital; Cincinnati Children’s Research Foundation; and Instituto Nacional de Ciencias Medicas y Nutricion–Mexico. Having discovered natural, anti-infective components (glycans) in human breast milk, demonstrated these components provide significant protection against infectious diarrhea. Have identified specific glycans unique to human milk having translational potential as novel therapeutic agents to promote healthy development and reduce risk of infection, inflammatory diseases, and adiposity. Has licensed intellectual property protecting these discoveries and inventions, and in process of developing methods for large-scale economic production of anti-infective glycans. Based on natural substances products proven to be safe and effective and, unlike antibiotics, will not promote pathogen resistance. New class of products promises to impact significantly scurge of infant/childhood diarrhea. Has partnered with Grameen Bank and Professor Muhammad Yunus, 2006 Nobel Peace Prize winner, to distribute products to children with greatest need, initially in Bangladesh. ...more |
| Helicos BioSciences Corporation |
Cambridge, MA |
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| Life sciences firm with developed technology focused to research, drug discovery and clinical diagnostics markets. True Single Molecule Sequencing (tS-MS) technology enables rapid analysis of large quantities of genetic material by directly sequencing single molecules of deoxyribonucleic acid (DNA) or single DNA copies of ribonucleic acid (RNA) (cDNA) and approach of direct sequencing of RNA. Genetic Analysis Platform designed to obtain sequencing information by repetitively performing cycle of biochemical reactions on individual DNA or RNA molecules and imaging results after each cycle. Platform consists of instrument: HeliScope Single Molecule Sequencer; an image analysis computer tower: HeliScope Analysis Engine; associated reagents: chemicals used in sequencing process & disposable supplies. ...more |
| Inanovate Inc |
Research Triangle Park, NC |
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| Leverages on unique nano-scale surface fabrication technology developed at University of Birmingham (UK). Novel approach to surface fabrication enable-d breakthroughs in protein micro-array surface technology, culminating in Inanovate’s first product; the i-Slide: World's premier surface for protein microarray experiments. Unique nano-scale surface technology integrated with novel protein screening procedures and detection systems to form basis of powerful point-of-care diagnostic system for early stage cancer. Operations in US and UK provide unique and powerful base to continue to grow as a leader in clinical and pre-clinical protein biochip systems ...more |
| MESH Inc |
Oxford, PA |
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MESH, Inc. is a small woman owned Pennsylvania Corporation located in Oxford, PA. MESH has specialized in Chemical Vapor and Aerosol Standoff Mo-nitoring for the DoD since 1988. MESH has extensive experience in the development of standoff sensors along with 3D Threat Cloud (Vapor or Aerosol) Mapping and Tracking, Prototyping Rugged Instrumentation, Algorithm Development and Embedded Software Development
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| Microbiotix Inc |
Worcester, MA |
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| Product-focused biopharmaceutical company engaged in the research and development of small molecule, anti-infective drugs that address commercially -significant medical markets. ...more |
| Nanocopoeia Inc |
St Paul, MN |
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| Nanocopoeia is a drug delivery company developing a nanotechnology-enabled portfolio of fast-to-market dermal and transdermal therapeutic products. Th-e firm’s business model is to enhance the value and performance of off-patent and OTC, already proven drugs by creating novel nanoformulations optimized for delivery into and through the skin. Nanocopoeia has developed a method using the firm’s ENS process that consistently results in multiplefold improvements in water solubility, or more precisely, “nanoscale suspendability.” ENS is used to create either bare drug nanoparticles or coated, core:shell nanoparticles in a single, “bottom up” processing step rather than a multi-step “top down” process like wet milling or homogenization; both are techniques used to break down larger, insoluble particles; requiring secondary processing to create a monodisperse range of particle size. A further advantage of ENS produced drug formulations is the ability to produce coated nanoparticles in that single processing step. The firm proposes to develop nanoformulations of topically applied drugs for acne, alopecia, and nail fungus. The Nanocopoeia ElectroNanosprayTM technology is based on a particle production design that creates the nanoparticles from the bottom up. Starting with the base compound in a solution or suspension, nanoparticles are generated in an ultra-pure, very uniform state. The particles can also be coated in a single operation. The solvent evaporates during the production process and results in highly uniform nanoscale dispersions of drug. The competitive advantage of the Nanocopoeia enabling technologies resides in: • Particle purity and uniformity: the ability to generate sub-200 nm particles with tight control over particle size by controlling operating parameters • Single-step process for particle production: using a “bottom up” approach that operates at normal pressures and temperatures, thereby minimizing processing damage to active compounds • Coating capability: drug particles can be formed and coated in one step with an extremely broad range of polymers, excipients and surfactants • This same process can be used to create therapeutic nanoparticle coatings for medical devices. ...more |
| Ogden Engineering & Associates LLC |
Tucson, AZ |
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Ogden Engineering & Associates, LLC is an engineering consulting firm specializing in Chemical Process and Environmental Engineering Services.&nbs-p; OE&A serves the defense, aerospace, energy, environmental and remediation, and biodiesil/biofuels industries
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| Orbis Biosciences Inc |
Kansas City, KS |
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| Orbis Bioscience provides novel controlled-release delivery systems to companies looking to reinvent their OTC products. Precision Particle Fabricatio-n produces uniform particles and capsules with narrow size distribution and exact control over particle structure. Clients use this elegant and robust solution to: 1) create differentiated products that are difficult for competitors to match, 2) innovate next-generation products with exactrelease profiles, and 3) leverage size uniformity for batch-to-batch reproducibility. Using this technology, Novartis could (1) gain unprecedented control of delivery rates for a variety of effects including fast action, rapid absorption, sustained release, and taste masking; (2) expand and improve delivery formats to include syrups, thin films, sprinkles, small pills, and sprays as alternatives to bulky tablets, patches, gums, or lozenges – offering flexibility in format options; and (3) improve drug performance with better exposure while reducing dosage frequency. Utilizing control of the particle and capsule physics, Novartis would have precise release rates and improved product quality through uniform, reproducible particles. Novartis would be able to achieve all of these improvements in a single step process by using Orbis’ PPF technology to manipulate key particle characteristics including size uniformity, shell thickness, and porosity. Orbis already works with multiple partners, leveraging the technology to enable new products through: (1) specific proof of concept development where Orbis develops customized formulations and the IP surrounding their manufacture, or (2) a research license in which Orbis provides the company with the technology for inhouse R&D and subsequent commercialization. Orbis’ exclusivity is on a product-by-product basis. There has been success with clients in the OTC space, and many other products still available for collaboration. ...more |
| Precision Combustion Inc |
North Haven, CT |
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| With a concentration to energy and chemicals sectors, the firm offers a series of catalytic reactor system breakthroughs supporting product advantage -for internal combustion and gas turbine engines, for fuel processing, for air emissions and VOC control, and for oil production. ...more |
| Quantalux LLC |
Ann Arbor, MI |
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| Provides innovative solutions in sustainable technology and energy systems - heating, cooling and alternative sources. Also developing new green build-ing materials for the construction industry. Can supply: Initial Technical System Design, Systems Prototype (Fabrication and Assembly), and Integration and Test ...more |
| Radiation Monitoring Devices Inc |
Watertown, MA |
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Grounded in high performance nuclear, optical, xray and magnetic sensors and systems, products and innovations span the fields of science, medicine an-d industry. Core technologies the CdTe detector which remains a significant part of commercial operations. Developed to commercial condition have been
- The Inspector® Lead Paint Analyzer, which employs a small CdTe detector to quickly make onsite determinations.
- Similarly based on CdTe, firm is an OEM supplier of a surgical probe system, The avigator®, to help physicians locate radio labeled cancerous tissue during surgery.
Current research activities in several programs are focused on semiconductor detector materials, scintillator screens, Si avalanche photodiodes (APDs) and nuclear instrumentation. Responding to medical imaging community's desire for more versatile, all solid-state designs, working on both semiconductor and scintillator solutions for next generation of digital radiographic systems
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| Silver Lake Research Corporation |
Monrovia, CA |
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| Silver Lake Research Corporation (SLRC) is a Southern California biotechnology company focused on development and manufacturing of novel antibody-base-d diagnostics. The Company has a proprietary immunization technology, the EAP System, that allows production of monoclonal antibodies to “difficult” targets that are not accessible to other antibody makers. In addition, SLRC has developed a series of patented formats for rapid immunoassay test kits, to take full commercial advantage of EAP-derived antibodies. The Company has an established design-developmentmanufacturing process, capable of developing and bringing to market entirely new diagnostic products in extremely short timelines. Taken together, these technologies provide the Company with a unique opportunity to develop new consumer-oriented rapid diagnostics and to maintain long-term market exclusivity for its products. SLRC is currently developing a new consumer diagnostic product under SBIR Phase II funding, and is seeking commercialization partners for this product. SLRC is also seeking development partnerships to leverage its proprietary technologies for the development of new products to be marketed by its partners. ...more |
| Spectral Sciences Inc |
Burlington, MA |
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| SSI is a research and development company dedicated to solving technical problems from concept to prototype for a range of clients in government and t-he private sector. SSI plays in areas as diverse as modeling the complex molecular interactions of rocket engine combustion and designing a new generation of remote sensing instrumentation for chemical and biological analysis. SSI scientists brings to bear a wealth of knowledge built over several decades to address new problems in remote sensing, spectroscopy, physical chemistry, combustion, atmospheric phenomenology and three dimensional imaging. SSI has developed industry-standard software models and analysis tools, as well as unique instrument prototypes to advance development of cutting-edge technologies. ...more |
| Surgisense Corporation |
Bethesda, MD |
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| Specializes in design, development, testing, manufacturing, and marketing of innovative new technologies for medical devices. Focused on developing ne-xt generation of “smart” sensing surgical instruments and medical devices to further enhance surgery, patient care, and patient safety. ...more |
| Thermalin Diabetes LLC |
Cleveland, OH |
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| Developing portfolio of insulin analogs to address both fast-acting and long-acting insulin markets. Developing several “insulin analogs” -— new proteins engineered to act like insulin in body. Insulin analogs are heat resistant, unlike natural hormone, which must be refrigerated. Resistance to heat makes analogs especially useful in insulin pumps worn outside body or in locations, like disaster sites, where there is no refrigeration. Company currently conducting large-animal tests. Expects to file with FDA an Investigational New Drug (IND) Application in 2012. Diabetes marketplace growing rapidly - from $12B to $54B in 20 years. ...more |
| Triton Systems Inc |
Chelmsford, MA |
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Triton Systems is a broad-based high-technology development/transfer firm actively pursuing niche markets in a wide variety of areas pertaining to adv-anced materials. Triton's business strategy is to identify unique and innovative solutions to complex problems by consulting its wide technology portfolio and delivering solutions that effectively address the problems at hand. The Triton Systems Materials Laboratories support a variety of programs in high performance materials. These laboratories comprise specific areas devoted to the developmental research, materials synthesis, specimen and prototype fabrication, processing, and testing necessary to the development of materials
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| Vecna Technologies Inc |
Greenbelt, MD |
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| Focused to advanced technology in three areas: Vecna Medical: driving force on important and exciting projects such as cutting edge Patient Self-Servi-ce solutions, Enterprise Web-based Systems and our QC PathFinder™ HAI Detection software for hospitals. Research includes NIH pathogen genotype/phenotype matching, new methods of syndromic surveillance and mobile health platforms. Business: focused on information integration for increased Productivity, Health & Wellness and Performance. Robotics: Vecna's robotics division is making history with the BEAR™, while the QC Bot™ is revolutionizing hospitals today. ...more |
| VPDiagnostics Inc |
Seattle, WA |
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| Provides plaque analysis software for vessel wall imaging enableing clinicians to identify and characterize high-risk atherosclerotic plaque before le-ads to strokes and other cardiovascular disease complications. Has develop evidence-based imaging solutions to non-invasively diagnose high-risk atherosclerotic plaque before rupture and to enable effective stroke preventive treatments. VPDiagnostics currently offers the FDA cleared software product: MRI-PlaqueViewTM. Characterization of plaque by MRI-PlaqueViewTM can assist clinicians in making management decisions and planning most suitable treatment. Enables timely and quantitative detection of disease progression in medical research and drug development. VPDiagnostics also leading an NIH-sponsored multi-center prospective clinical trial to evaluate a new diagnostic utility for use with MRI-PlaqueViewTM that will enable prediction of future risk of stroke and related neurological complications based on plaque characteristics. ...more |
| Weinberg Medical Physics LLC |
Bethesda, MD |
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| Invented application of dedicated devices for molecular breast imaging. Two companies founded successfully in-troducing positron emission mammography- and dedicated scintimammography devices. Principals have applied pulsed power switching techniques typically employed in plasma physics to ultrafast MRI gradient generation. Current projects include * Ultra-fast MRI * Monitoring of proton therapy * Quantum dot radiation detectors * Mesoscale wound healing devices * Low-dose molecular imaging, Launched four FDA-approved medical devices over the past two decades. Two have been used to detect breast cancer, and received product-of-the-year awards from Frost and Sullivan. ...more |
| Zybek Advanced Products Inc |
Boulder, CO |
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Zybek Advanced Products specializes in extreme thermal reacting plasma systems. The firm has produced specialized milling production capability -for advanced nano-material manufacturing and processing, and offers highly sophisticated fabrication services. ZAP’s technology is applied to clean coal processing, NASA’s lunar simulant production, nano-materials, and greener container glass manufacture. Zybek Advanced Products (ZAP), Inc., is an industrially focused company with research facilities that are supported by its industrial roots. Because equipment and devices are easily fabricated within ZAP’s facility, research and development experiments and production efforts have a fast path for new or replacement parts. The analytical skills of the firm's personnel are coupled with a fast track Edisonian research capability to allow ZAP to advance its technology more quickly than in traditional companies. ZAP was a finalist in the Boulder County Business Report IQ Awards. Zybek Advanced Products is proud to be an eSpace supported company. ZAP leverages its industrial infrastructure to obtain maximum return for customer’s dollars. With its facility, investments and personnel, ZAP has successfully completed research and developed processes beyond technology readiness and into commercialization.
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