Company Capability Nutshell:
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  • Accepted Nutshells from those who are Event-involved - as selected presenter or observer - will be entited to a $100.00 credit on applicable Event Fee
  • Those not participating in March 19-21, 2008 in Boston, but instead opting to let their Nutshell stand on its own, will have paid $250.00 for posting and distribution of their piece
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    Useful Nutshell content and layout: Examples
    In this part of the site are listed the Company Capability Statements accepted from a range of SBIR Awardees variously involved in doing what can be judged leading-edge work in their space.
         Acceptance of Nutshells is NOT automatic. As received, all applications are carefully reviewed by the Evaluation Team. Some will be edited; a few will be returned for major re-write.
         In this context, it is important to stress that what the firm has accomplished in SBIR - in terms of what technologies have been developed, what business milestones may have been reached - is actually less important than how what that firm has achieved to date is evidence of what they are capable of doing. In other words, the focus here is to in-place skills sets and to demonstrated capabilities as much as it is to specific technology accomplishments for possible insertion.
    Capability Statements: exposure
    Capability Statements are a useful and potentially important Marketing Tool for this event and subsequently.
       Whether those selected are Event-involved or not, all accepted Company Capability Statements will be posted here on this site for relevant Tech Seeker access and review - see below - AND will be on the Event CD which will be part of the Event Package and that which is used in any post-event distribution.
       All SBIR Awardees with an accepted Capability Statement who opt to participate in the SBIR ASSETs event will be provided opportunity for a FIVE minute Plenary Session Nutshell presentation

    Tech Seekers ONLY:
    For the near-term, it is IMPORTANT TO NOTE that access to these Company Capability Statements is limited to Registered Tech Seekers. Tech Seekers are reminded that though these Capability Statements may likely include those of SBIR Awardees who are responsive to their Issued Topics with prepared White Papers, this area of the site is in addition to that customized process and will usually have a more general applicability.

    What should be in my company Nutshell?
    Number of Nutshells to date: 64
    Name of Firm City, State Company Nutshell Business Profile
    13therapeutics Inc Portland, OR
          Formerly doing business as Targeted Gene Delivery Inc, 13therapeutics is a research and drug development company focused on the identification and characterization of novel anti-inflammatory peptides for unmet medical needs with high commercial potential. The Company has an innovative platform for isolating novel peptides from immunoregulatory proteins, produced by pathogens, which impact the immune system. These identified peptides have application in the treatment of both acute and chronic inflammatory diseases.
    Accord Biomaterials Inc Ann Arbor, MI
          Focused to work involving biomarker assays and diagnostic tools targeting s-nitrosothiols (RSNOs) to assess disease states in which pathways involving nitric oxide (NO) and its physiologic carrier RSNO are implicated.
    Adarza BioSystems Inc West Henrietta, NY
          Formerly doing business as Pathologics, LLC, engaged in developing a rapid label-free multiplex immunoassay platform focused on research applications in environmental exposure, cancer biomarkers, and infectious disease.
    Agile Sciences Inc Raleigh, NC
          Technology is based on a family of novel organic compounds that have potent anti-biofilm properties. The molecular architecture of the compounds is highly tunable for addressing specific needs in a diverse array of product markets. •Disperse pre-existing or inhibit the formation of bacteria-l biofilms across order, class, and phylum •Exhibit activity under both static and flow conditions, relevant to biological and industrial systems. •Inhibit the formation and disperse pre-formed bacterial biofilms on metal, plastic, and mucin surfaces. •Increase the effectiveness of antibiotics toward antibiotic resistant bacteria (MRSA and MDRAB)
    Angion Biomedica Corporation Garden City, NY
          A clinical stage biopharmaceutical company focused on developing small molecule drugs to treat life threatening diseases related to acute organ injury (e.g. kidney, liver, lung, transplantation)and chronic fibrosis (e.g. liver, lung).
    APC Biotechnology Services Inc Rockville, MD
          Novel bioprocess platform; recombinant peptides and small proteins; vaccines; custom immunogens; therapeutics. Firm has developed a novel peptide and protein bioprocess platform with which to offer custom recombinant peptide or protein synthesis and bio-process development services. A complete set of custom product development services, product-specific assay development (including ELISA) and analytical testing services are offered for clients with recombinant protein and peptide drugs
    Aphios Corporation Woburn, MA
          Specialty pharmaceutical company developing enhanced natural therapeutics for health maintenance, treatment of cancer and infectious diseases. Using Company's library of diverse marine microorganisms isolated from normal to extremeophilic environments in United States territorial waters, developing antiviral and antimicrobial therapeutics. Portfolio includes several anti-HIV, anti-Influenza and anti-Smallpox 'hits,' and a marine antimicrobial compound effective against multi-drug resistant (MDR) human pathogens, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE). Proprietary products in: 1) low temperature viral inactivation for blood plasma, animal serum and recombinant therapeutics; 2) natural product manufacturing for therapeutics such as Taxol and other anticancer agents; 3) liposome formulation of chemotherapeutic drugs and recombinant proteins; and 4) selective microbial cell disruption for the recovery of intracellular proteins and periplasmic enzymes.
    Atom Sciences Inc Oak Ridge, TN
          Specialize in detection of extremely small quantities of atomic or molecular species on surfaces, in bulk gases, liquids, or solids enabling surface analysis to include semiconductors as well as DNA diagnostics. The firm undertakes design engineering, research and analysis services in advanced materials, biotechnology, chemicals and environmental applications. Currently working on Resonance Ionization Spectroscopy with a strong emphasis to biotech innovations to develop improved DNA diagnostics.
    Auritec Pharmaceuticals LLC Santa Monica, CA
          Focused on its proprietary technologies for targeted and sustained drug delivery.
    AvidBiotics Corporation South San Francisco, CA
          Protein engineering targeting: for the treatment of specific bacterial diseases of humans, with particular emphasis on antibiotic-resistant bacteria.
    BioHelix Corporation Beverly, MA
          BioHelix Corporation uses its proprietary isothermal DNA amplification technology to develop "instrument free", disposable molecular diagnostic tests.
    Biomedical Development Corporation San Antonio, TX
          Primary research interests involve infection control and topical/transdermal drug delivery systems. Areas of technology interest include: Unique Protective Barrier for Incontinence * One-Step Antimicrobial Surgical Preparation and Incise Drape * Drug Delivery System for Superficial Mycoses in AIDS * Combination Occlusive Dressing/Drug Delivery for Psoriasis* Unique Treatment for Bovine Mastitis. Disinfectant Technology Abstracts include: Reduction of Biofilms in Dental Unit Waterlines * Dialysis Disinfectant Replacing Formaldehyde Sterilants * Treatment for GBS Colonization in Pregnant Women
    BioSensors Inc Schenectady, NY  
          Company utilizing a novel combination of Electromagnetic Impedance Spectroscopy and Electromagnetic Impedance Tomography for the noninvasive monitoring of important blood metabolites and electrolytes. Company mission is to (1) develop a non-invasive, continuous blood glucose monitor for the treatment of diabetes for license or sale to a major biomedical instrument or pharmaceutical company and (2) maintain the proprietary rights to our platform technology for applications other than diabetic glucose monitoring.
    Breonics Inc Albany, NY  
          Biomedical Research and Development company applying its novel bioengineering technologies to develop innovative medical products for the clinical organ transplant and tissue replacement markets.
    C56 Technologies Middleton, WI
          Focus is to technology and discovering of biomolecules to convert agricultural and forestry feedstocks to five and six carbon sugars for processing into biofuels. Starting points of C5•6’s enzyme discovery process are microbes selected from targeted natural environments. Using its platform tools, C5•6 has isolated and is commercializing a series of thermostable enzymes tailored for the high-temperature, harsh pH environment of the dry mill ethanol facility.
    Calista Boston, MA
          A gene expression profiling panel to recommend treatment and predict outcome in Stage II and III colorectal cancer.
    Cardax Pharmaceuticals Inc Aiea, HI  
          Developing proprietary small molecule therapies for large un-met medical needs where inflammation driven by oxidative stress plays an important causative role, including metabolic syndrome, liver disease, cardiovascular disease, macular degeneration, and prostate disease.
    CFD Research Corporation Huntsville, AL
          A mature, larger small firm firm, CFD Research Corporation (CFDRC) now offers capabilities in two areas - Biomedical and Emerging Energy and Materials Technologies and - Aerospace and Defense Solutinons. Microfluidic systems (lab-on-chip); 1. Biochips for Synthetic Microvasculature Networks Biomedical devices; Computational Medicine, Systems Biology, and Bio-Informatics. Work in Emerging Energy & Materials technologies includes biobattery, fuel cells, quantum dot solar cells, (nano-)materials processing and fabrication.
    Ciencia Inc East Hartford, CT
          Integration of fluorescence sensing instrumentation with surface plasmon resonance based optical analysis instrumentation targeted to broad applications in biological research and environmental monitoring. Custom instrumentation design and prototype development to meet a wide range of specific applications in research and clinical diagnostics.
    Clark-MXR Inc Dexter, MI
          Provides non-thermal micro/nano-machining of any material with ultrafast lasers. High quality, high yield results with no heat affected zone (HAZ), no embrittlement, no recast layer, no splatter, no microcracks, and no delamination. Process yields precise, repeatable results that are independent of the type of material.
    Cognosci Inc Research Triangle Park, NC
          Anti-inflammatory compounds for treatment of neuroinflammatory diseases such as Multiple Sclerosis, Alzheimer's Disease, and Traumatic Brain Injuries - disorders having pharmacogenomic linkage to the apolipoprotein E (APOE) protein and people with the å4 allele typically suffer worse outcomes. Based on these findings, scientists from Duke University created novel APOE-based compounds that have potent anti-inflammatory and neuroprotective activities.
    Creatv MicroTech Inc. Potomac, MD
          Diagnostic kits and analytical tools, reagents and services for the medical, water, food, environmental and pharmaceutical industries. Platform more rapid and sensitive than traditional methods. • sensitive and rapid assays and kits for the detection of pathogens and toxins in food, water and environment, • medical diagnostics, such as prognostic test for chronic lymphocytic leukemia (CLL) and a patient monitoring test for diabetes, • ultra-sensitive spectrofluorometer instruments, and • a vaccine for Neisseria gonorrhoeae.
    Curio Systems Inc Oak Hill, VA
          Automated rare event statistical analysis, surveillance and reporting. A new and innovative approach to analyze rare events in ways not currently served by existing market offerings and without the need for advanced statistical analysis expertise. Potentially powerful tracking applications include:
  • Pharmaceutical companies tracking production errors, clinical trial results, patient side effects, etc.
  • Clean energy companies tracking pollutant emissions, emissions control efforts, etc.
  • Blood and plasma banking organizations tracking donor population rates of infectious disease markers, donor deferrals, etc.
  • Public health organizations conducting biosurveillance of infectious disease outbreak markers, public health risks, etc.
  • Port security officials tracking inspection results of container security inspection reports for contraband shipments, by shipper, shipment type, etc.
  • Hospitals tracking the numbers and types of hospitalacquired infections, such as MRSA, ventilatoracquired pneumonia, etc.
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    DiscoveryBioMed Inc Birmingham, AL
          Pilot screening and high-throughput screening (HTS) services for therapeutic-related bioassays, providing partners and clients custom immortalized cell-line models and performs therapeutics discovery for certain failure-to-secrete diseases in humans
    Echelon Biosciences Incorporated Salt Lake City, UT
          Focused to cell signaling, i.e. the molecules and processes by which cells communicate and respond to their environment.
    EIC Laboratories Inc Norwood, MA
          Parent company has expertise in lithium and lithium-ion batteries, electrochromics, Raman and other spectroscopic sensors and instruments, electrodes and materials for functional electrical stimulation, chemical sensors and advanced organic materials design and synthesis. Recently spun-out EIC Biotechnology team integrates capabilities in materials science, molecular biology and analytical instrumentation to diverse problems relating to biotechnology, biosensing and human health. • Medical electrodes group develops and tests a range of coatings such as iridium oxide to enhance performance of bioimplantable devices for electrical stimulation and sensing, as well as in vitro testing and models for electrode evaluation. • Synthetic chemistry group designs and implements strategies for modifying biological molecules, creating bioconjugates, attaching bioactive materials to surfaces, and for targeted drug delivery. • Molecular biology group addresses a range of problems in biotechnology, including bioprocess monitoring, developing novel affinity labels, and designing strategies and microfabricated platforms for parallel immunoassays.
    Endacea Inc Research Triangle Park, NC
          Working on a series of proprietary A1 adenosine receptor (AR) -antagonists as drug candidates for medical indications, including renal impairment associated with acute or chronic heart failure, as well as with nephrotoxins, e.g. cisplatin-induced renal impairment, inflammation, including asthma and sepsis, and for biodefense indications as a medical countermeasure for weapons of mass destruction, including plague, tularemia, and ionizing radiation induced organ injury from a "dirty bomb."
    Endomedix Inc Stony Brook, NY
          Highly biocompatible, biodegradable, environmentally-responsive, natural hydrogel for multiple medical applications. Similar to fibrin glue containing two stable components at room temperature, core components are not derived from synthetic materials or blood products. Initial cytotoxicity data shows minimal inflammatory reaction. Applications in wound care, tissue sealing, vascular surgery, general surgery, spine surgery, ophthalmic surgery, neurosurgery, and drug delivery. Current preclinical studies focused on (1) wound care showing improved efficacy over silvadene; (2) vascular embolic for the treatment of abdominal aortic endoleaks, arteriovenous malformations, and brain aneurysms; (3) tissue sealing; (4) hemostatic agents; and (5) spinal applications.
    Housey Pharmaceutical Research Laboratories Southfield, MI
          Leveraging on in-house expertise in the field of cell-based assay technology, by combining it with additional technologies, present concentration is specific forms of human cancer and type II diabetes. Has relevance to other therapeutic areas including central nervous system disorders, autoimmune disorders, and infectious disease.
    Humanitas Inc Silver Spring, MD
          Automated tools and technology solutions to assist health professionals manage cancer clinical trials overseen by the National Cancer Institutes (NCI) Cancer Therapy Evaluation Program (CTEP). Products include ePanel© - a web-based review management system used to facilitate streamlined reviews. Web TIE - a gateway for interactive, web-based applications for health professionals participating in clinical trials. Common Toxicity Criteria (CTC) for palm devices/PDAs - provides health professionals access to NCI/CTEPs CTC repository for use in adverse drug experience reporting, Adverse Events (AE) summaries, Investigative New Drug (ING) reports to the FDA, and publications. eMobile, a remote data collection and reporting application that operates on a wireless mobile device.
    Impact Technologies LLC Rochester, NY  
          Analysis, prediction and management of the health of critical assets
    INCELL Corporation LLC San Antonio, TX
          Biotechnology company with a strong product pipeline in two core technology sectors: (1) vaccines and infectious disease and (2) regenerative medicine and Stem cells.
    Infoscitex Corporation Waltham, MA
          With emphasis on advanced materials technologies and systems engineering, products currently under development include
  • prosthetic spinal disc,
  • single stage immunoassayintegrated microfluidic device,
  • battlefieldready needlefree delivery system to protect against organophosphorousbased nerve gases,
  • implantable artificial lung,
  • microrobotic prototype for neurosurgery, 6) urinary drainage catheter stent lock mechanism,
  • low VOC sealants,
  • biosynthesis of energetic materials and their precursors,
  • home care “Active Bottle” for dysphagic infants,
  • electroactive polymer based strategically tuned absolutely resilient structures,
  • wastetoenergy conversion processing system,
  • selfenergized casualty patient warming device,
  • radiationhardened solar cell windows
    • Innovative Surface Technologies Inc Saint Paul, MN
          Surface modification through chemical bond formation with devices and biomoleules for health care, biosensors, and high value industrial products. Primary technology focus: preparing and using surface modification reagents for diagnostic, drug delivery, device coating and other biomaterial and biotechnology markets. Work based primarily on new latent-reactive reagents for covalent bonding under gentle, manufacturing friendly reaction conditions, of biomolecules, polymers, and micro/ nanoparticles with other surfaces and with one another. Thin-film surface modifications are being developed and demonstrated for improved wet ability, wet lubricity, biomolecule immobilization and super- hydrophobic surfaces. Examples: • Nanotextured superhydrophobic coatings • Ultrathin (monolayer) coatings for diagnostic microspheres • Biomolecule immobilization for antimicrobial applications • Lubricious coatings • Proprietary photoactivatible crosslinking reagents • Nanofibrillar surfaces for cell culture and tissue engineering • Custom designed coatings for specialty applications
    ISA Associates Inc Alexandria, VA
          Behavioral health R&D firm specializing in the development of advanced computer-based health improvement programs in the areas of nutrition/weight management, HIV, stress management, substance abuse, ADHD, medication adherence and cardiovascular risk reduction.
    Javelin 3D Park City, UT  
          Specializes in architectural models, medical and anatomical prototypes, high-end CAD verification, sculpted art pieces, and invention concepts.
    Key Technologies Inc Baltimore, MD
          High-tech product design and applied research prototyping company
    Lynntech Inc College Station, TX
          A long-time involved, substantial player in the SBIR-STTR space with demonstrated ex-pertise in
  • Alternative Energy (fuel cells, hydrogen production, plasma reforming)
  • Biotechnology and Health (therapeutics, diagnostics, sensors, disinfection, decon-tamination, drug delivery)
  • Chemical Synthesis (ozone, chlorine dioxide, hydrogen peroxide, ferrate, diper-oxyacids)
  • Environmental (soil, drinking water, indoor air, vehicle and industrial emissions)
    • MBC Pharma Inc Aurora, CO
          Discovery and development of bone-targeted chemotherapies for metastatic bone disease, bone cancer and bone infection. Patented technology is built on exploiting bone seeking properties of a well-known class of antiresorptive agents called bisphosphonates, to deliver chemotherapeutic payload directly to the cancer-induced sites of bone destruction.
    Medennium Inc Irvine, CA
          A spin off from Pharmacia & Upjohn Center of Excellence for Foldable Intraocular Lenses. Currently producing intraocular lens and punctum plug products. Patented shape memory polymer family used for the SmartPlug one-size punctum plug for dry eye and the platform for the firm’s intraocular lenses implanted through small incisions. Line of innovative ophthalmic products made from patented materials.
    Molecular Express Inc Rancho Dominguez, CA
          Innovative Biotech company with lipid and "Molecular Guided Particle System" (Molecular GPS™) delivery platform forming the basis for active programs targeting anti-cancer therapeutics, drug delivery systems, vaccines, and nanoparticulate drug delivery technologies. Applying the Molecular GPS™ technology platform to develop vaccines for influenza, herpes, HIV, Anthrax and A. fumigatus. Studies suggest Molecular GPS™ technology platform can be used to develop a variety of therapeutics to combat cancers and emerging infectious diseases.
    NanoScale Corporation Manhattan, KS
          Grounded in anocrystalline metal oxides (anoActive materials) and technologies originally developed at Kansas State University, firm can now accommodate production from small research samples to largescale production of specialized chemicals. In place products include
  • FASTACT: a chemical containment and neutralization system that allows first responders to immediately mitigate toxic chemical releases, including industrial chemicals and chemical warfare agents.
  • anoActive Chemicals: High performance metal oxides that possess unique and uncommon characteristics effective against a wide range of harmful or deadly chemical substances and hazardous compounds, odors, environmental pollutants, toxins, bacteria, viruses, and fungi.
  • anoZorb: a remarkable odor destroying product for use by morgues and funeral homes that is effective against odors commonly associated with decomposition.
  • ChemKlenz: a multiphased safety program that provides facilities and institutions unparalleled immediate response capabilities against unexpected chemical spills and releases.
  • OdorKlenz: the next generation of products and services for the elimination of challenging odors caused by tobacco smoke, spoiled foods, pets, flooding, decay, cleaning products, and industrial chemicals, as well as other noxious odors
    • Neurobiotex Inc Galveston, TX
          Developing research tools, diagnostics, and therapeutics for zinc related diseases. Particular focus on ionic zinc signals with considerable research effort to determining physiological concentration of ionic or “free” zinc in biological fluids such as the CSF, blood serum, saliva, semen, tears, and the intracellular fluids of cells. Tools developed to measure free zinc in the physiological range; for imaging free zinc in the appropriate range(s;) and for buffering free zinc to the correct levels for maintaining and studying cells and tissue in vitro.
    Newton Photonics Inc Newton, MA
          Application of advanced photonic sensing technologies to medical device and life science instrumentation markets combining optical design with electronic signal processing to provide products that offer paradign-shifting performance. Current developments include a non-invasive (optical) glucose monitor with accuracy comparable to test strips and label-free SPR sensor for analysis of biomolecular interactions with 100x sensitivity advantage over the best commercial systems.
    Physical Sciences Inc Andover, MA
          A longtime established R&D firm with capabilities in * Chem-Bio Remote Sensing * CBN Sensor Architectures *Terahertz Sensors * Remote Gas Detection * Industrial Process Sensors * Harsh Environment Sensors * Fuel Contamination Monitor * Solid State Dye Lasers * Solid State High Power Lasers * Laser Display Technology * Nonlinear Optical Materials * Laser System Diagnostics * High Temperature Materials * Space Technologies * Advanced Power Sources * Ophthalmic Monitoring
    Piezo Resonance Innovations Inc Bellefonte, PA
          Focus on smart materials technologies - piezoelectric, electromagnetic, shape memory or magnetostrictive – for use in medical devices. Offer solution to device actuation challenges faced by medical product development teams.
    Plant Sensory Systems LLC Baltimore, MD
          Through genetic modification, optimizing ability of plants to acquire and utilize nutrients to increase biomass, yield, and quality.
    PlastiPure Inc Austin, TX
          Plastics and food antioxidants free from endocrine disruptors. New polymer formulations and plastic items safer for consumer use. Applications in food and beverage, pet food, infant feeding, personal care, packaging, cosmetics, medical supply, pharmaceutical, toy, and other industries.
    Precision Combustion Inc North Haven, CT
          With a concentration to energy and chemicals sectors, the firm offers a series of catalytic reactor system breakthroughs supporting product advantage for internal combustion and gas turbine engines, for fuel processing, for air emissions and VOC control, and for oil production.
    Pressure BioSciences Inc Rockville, MD  
          Rapid cycling of hydrostatic pressure between ambient and ultra high levels used to control biomolecular interactions, allowing for a high degree of precision, reproducibility, convenience, speed, and safety. Potential for broad applications in genomics, proteomics, drug discovery & development, process purification, pathogen inactivation, immunodiagnostics, and DNA sequencing.
    Pulmotect Inc Houston, TX  
          Leaders in emerging science of innate immunity in the lungs. Products being developed that boost that innate immune system to protect against a wide range of lung infection. Stimulate body’s natural defenses to provide safe, broad-spectrum, fast-acting protection against bacterial pneumonia (including MRSA), influenza, fungal pneumonia, and Class A bioterror agents (including anthrax, tularemia, and plague).
    Radiation Monitoring Devices Inc Watertown, MA
          Well established firm using high performance optical, nuclear and magnetic sensors utilized in a range of applications to include • X-ray, gamma ray, neutron detectors • X-ray , gamma ray, neutron imaging • Non destructive testing • RoHS, lead testing • Nuclear medicine instrumentation • Homeland security • Biosensors • Coulter cells and microfluidics
    RHEONIX Inc Grand Island, NY
          Integration of biosensor capabilities with microfluidic technology designed to provide Point of Care and Point of Use diagnostic platform with broad application to include human and veterinary in vitro diagnostics, biopharmaceutical manufacturing, food and beverage manufacturing, food and water safety testing, and homeland security /defense applications.
    Science and Sensors Technologies El Segundo, CA  
          Develops and manufactures optical fiber sensors for the construction, environmental, educational, aerospace and agriculture markets. Patented sensing technology delivers multi-point, multi-parameter sensing capability with high spatial resolution at a fraction of the cost of devices already in place.
    Scout Diagnostics LLC Louisville, KY
          New diagnostic tool enabling very early determination of Alzheimer. New tool initially allow testing efficacy of new treatments; eventually will enable early diagnosis, providing option to begin early-stage treatment treatments can be the most beneficial. Effort grounded in discovery of aberrant protein complex found in post mortem and living subjects that either have or are in the process of becoming diagnosed with mild cognitive impairment, early stage Alzheimer's Disease (AD) or late stage AD. In the field of Alzheimer’s disease (AD) research, three observations have received the greatest attention; the appearance of amyloid plaques, the appearance of neurofibrillary tangles, and the presence of neuroinflammation (inflammatory response). The holy grail of AD research has been the search for a single unifying event that would lead to all three hallmarks of the disease. Scout Diagnostics has data that the protein complex is the event. Research shows that know protein complex (biomarker) produces paired helical filaments (PHFs) in cell culture - precursor of neurofibrillary tangles; protein complex causes increased production of the beta amyloid peptide in cell culture and the beta am-loid peptide increases production of the protein complex in choroid plexus cells; results indicate that protein complex activates inflammatory response elements in astrocytes. Holy grail found: single event in pathogenesis of AD tying together all current hallmarks.
    Sea Run Holdings Inc Freeport, ME
          Marine biotechnology company that develops innovative biologics from the blood of farmed salmon. Focus is on therapeutics from salmon fibrinogen and thrombin which in animal trials have shown remarkable efficacy for traumatic brain injury, spinal cord injury, pain, and traumatic bleeding.
    Silver Lake Research Corporation Monrovia, CA
          New immunization system to generate rapid and powerful immune response to a wide range of antigens. Proprietary system: a broadly applicable methodology enabling unprecedented predictability and control over the immune response to even the most "non-immunogenic" antigens. EAP technology platform now being applied to development of monoclonal antibodies for therapeutics, diagnostics, and research uses, where rapid and reliable induction of high-affinity MAbs is crucial.
    Statistical Innovations Inc Belmont, MA
          Experts in statistical modeling. Software developer for advanced statistical analyses including: • Latent GOLD -- The #1 program for latent class/finite mixture modeling CORExpress: Currently under development -- for reliable predictive models based on possibly thousands of predictor variables/ gene expression/ and an advanced step-down algorithm to reduce the number of genes to the core set (patent pending)
    Stellarray Inc Austin, TX
          Grounded in technology developed by parent company safely and rapidly to decontaminate biohazards such as anthrax. – use of flat panel radiation sources for use in sterilization of medical products, pharmaceuticals and in-hospital items. Early focus: self-contained irradiators using FPXS panels, especially for transfusion blood supplies, to replace radioactive isotope systems. Firm’s digitally addressable X-ray source (DAXS) to work on stand-alone X-ray tubes enablimg computed tomography (CT) systems with no moving parts. An early DAXS CT system will be for in vivo small animal imaging, to enable the first clear radiographic images of the mouse cardiovascular system.
    Terpenoid Therapeutics Inc Coralville, IA
          With expertise in the biology and chemistry of terpene metabolism, pharmacology and oncology, focused on cancer. using platform of terpene chemistry to develop candidate drug molecules. Two current projects • small molecule inhibitors of geranylgeranyl diphosphate synthase, a novel target with applicability towards cancer and other indications. • schweinfurthins, a family of novel cytotoxic agents with applicability towards cancer.
    TSRL Inc Ann Arbor, MI
          Oral drug delivery specialty firm focused to enhancement of oral absorption of drug candidates. • Patented technologies for improving oral absorption of drug candidates, including pro-drug and carrier technologies as well as time and rate controlled delivery systems. • Promising product pipeline with oral candidates for treatment of osteoporosis, influenza, CMV and smallpox.
    Virginia Technologies Inc Charlottesville, VA
          Electronic instrumentation to include a neurostimulator and Quantitative Light Standard, a new technology enabling testing of light source and detection systems in microscopes and microplate readers.
    VisionQuest Biomedical LLC Albuquerque, NM
          Automated screening of retinal images for detection of eye diseases. Medical Image Analysis Ophthalmology • Computer-aided Diagnosis • Radiology • Multispectral Image Analysis • Dermatology • Optical Imaging Devices • Medical, Functional Image Analysis
    Xhale Inc Gainesville, FL  
          Breath-based technologies offering the potential to improve quality of health care through innovations in personalized medicine. Applications in medical, home, law enforcement and industrial diagnostic markets.